Whom is doing the followup research that will prove what level of this training will get survivors to 100% recovery?
Is early initiated cardiorespiratory fitness training within a model of stroke-integrated cardiac rehabilitation safe and feasible?
Section snippets
Methods
This study had ethical approval from Epworth HealthCare Human Research Ethics Committee (ID: EH2017-282), and the University of Melbourne Psychology Health and Applied Sciences Human Ethics Sub-Committee (ID: 1954294).
Study Design
This was a single centre, multi-site, prospective cohort feasibility study. All people with stroke were screened for eligibility after admission to subacute inpatient rehabilitation facilities at Epworth HealthCare from April 2018 to December 2020.
Participants
All potential participants that met the inclusion criteria were approached on admission to subacute rehabilitation. People with stroke were eligible to participate if they were: 1) ≥18 years of age, 2) diagnosed with an acute first or recurrent ischaemic stroke, 3) able to provide consent, and 4) able to comprehend verbal and/or written commands. People with stroke were excluded from the study if they: 1) were pregnant, 2) had significant musculoskeletal or pain issues that precluded
Procedure
Demographic data (i.e., participant's age, medical history, stroke diagnostics [date, type, location, clinical manifestations]) were collected from each participant's on-site medical record.
Intervention
Like traditional CR programs,35, 36, 37 the stroke-integrated CR program designed for this study consisted of inpatient (Phase 1) and outpatient (Phase 2) rehabilitation. To investigate the safety and feasibility of early initiated stroke-integrated CR, participants were recruited as soon as possible after admission to inpatient rehabilitation at Epworth HealthCare. Participants were able to consent to either Phase 1, Phase 2 or both. For example, participants who were unable to return to the
Demographic Data
Demographic data collected included stroke severity (National institute of Health Stroke Scale),40,41 disability (Modified Rankin Scale),41,42 functional measures (Functional Independence Measure),43 and measures of fatigue (Fatigue Assessment Scale).44,45
Safety
Safety was assessed by recording all adverse and serious adverse events during the study. An adverse event was defined as any untoward medical occurrence (i.e., exacerbation of a pre-existing condition, or a new condition or diagnosed after participation in the study) experienced by participants while participating in or immediately following the study. A serious adverse event was defined as an event resulting in death, was life threatening, required hospitalisation or prolonged existing
Results
We screened 164 individuals admitted to two subacute inpatient rehabilitation facilities at Epworth HealthCare in Melbourne, Australia (Fig. 2). Of the 117 (71.3%) people with stroke eligible to participate, 55 (47%) declined consent or were not recruited, with the primary reasons being too overwhelmed to participate (n= 21), declined but no reason given (n= 15), a lack of time (n= 11), no transportation to attend rehabilitation (n= 4), lived rurally (n= 3), and deceased prior to consent (n=
Discussion
The results of this study demonstrate early initiated cardiorespiratory fitness training within a model of stroke-integrated CR appears to be safe for people with mild and mild-to-moderately severe stroke, with no study-related serious adverse events observed. Despite moderate rates of recruitment (53% of eligible people with stroke) and attendance to the education sessions (57.7%), the early initiated stroke-integrated CR program tested in this study demonstrated high retention (84%) and
Conclusions
Cardiorespiratory fitness training, as recommended by multiple clinical practice guidelines, appears to be safe and feasible within a model of stroke-integrated CR in the early subacute phase. Despite high attendance and retention rates, not all people with stroke want, or were able to access centre-based CR. There is a critical need for more accessible models of post-stroke rehabilitation, potentially including home-based or telehealth models with flexible days or hours of attendance to
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