So we still KNOW NOTHING ABOUT CURING POST STROKE FATIGUE!
WHOM is going to do the further research that will solve this problem? Specific names only.
Non-pharmacological interventions for the treatment of post-stroke fatigue: A systematic review
Abstract
Background:
Post-stroke fatigue (PSF) affects 50% of stroke survivors. Current guidance on management(Survivors want it cured, NOT MANAGED!)of this condition is limited.
Aims:
This
systematic review and meta-analysis aimed to identify and analyze all
randomized clinical trials (RCTs) of non-pharmacological interventions
for the treatment of PSF.
Summary of review:
Six
electronic databases were searched from inception to January 2023 for
English-language RCTs investigating the efficacy of non-pharmacological
interventions versus passive controls in patients with PSF. The primary
outcome was fatigue severity at the end of the intervention. The
Cochrane risk-of-bias (ROB)2 tool was used to assess evidence quality. A
total of 7990 records were retrieved, 333 studies were scrutinized, and
13 completed RCTs (484 participants) were included. Interventions
included psychological therapies, physical therapies, and brain
stimulation. Nine studies provided sufficient data for meta-analysis, of
which seven also had follow-up data. Fatigue severity was lower in the
intervention groups at the end of the intervention compared with control
(participants = 310, standardized mean difference (SMD) = −0.57, 95%
confidence intervals (CIs) (−0.87 to −0.28)) and at follow-up
(participants = 112, SMD = −0.36, 95% CIs (−0.83 to 0.10)). Certainty in
the effect estimate was downgraded to low for a serious ROB and
imprecision. Subgroup analysis revealed significant benefits with
physical therapy and brain stimulation but not psychological therapies,
though sample sizes were low.
Conclusion:
Non-pharmacological
interventions improved fatigue but the quality of evidence was low.
Further RCTs are needed for PSF management.
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