Deans' stroke musings: Microglia protect against age-associated brain pathologies

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 20, 2024

Microglia protect against age-associated brain pathologies

If you have a competent? doctor they will get human testing going and create interventions that save these microglia! Do you have a competent doctor?

Microglia protect against age-associated brain pathologies

Open AccessPublished:June 18, 2024DOI:https://doi.org/10.1016/j.neuron.2024.05.01

Highlights

•
Lack of microglia leads to progressive brain calcifications and macroglial reactivity
•
scRNA-seq reveals brain cell profiles across the lifespan in the absence of microglia
•
The thalamus is particularly sensitive to the absence of microglia with aging
•
Transplanting microglia protects against pathology development

Summary

Microglia are brain-resident macrophages that contribute to central nervous system (CNS) development, maturation, and preservation. Here, we examine the consequences of permanent microglial deficiencies on brain aging using the Csf1r^{ΔFIRE/ΔFIRE} mouse model. In juvenile Csf1r^{ΔFIRE/ΔFIRE} mice, we show that microglia are dispensable for the transcriptomic maturation of other brain cell types. By contrast, with advancing age, pathologies accumulate in Csf1r^{ΔFIRE/ΔFIRE} brains, macroglia become increasingly dysregulated, and white matter integrity declines, mimicking many pathological features of human CSF1R-related leukoencephalopathy. The thalamus is particularly vulnerable to neuropathological changes in the absence of microglia, with atrophy, neuron loss, vascular alterations, macroglial dysregulation, and severe tissue calcification. We show that populating Csf1r^{ΔFIRE/ΔFIRE} brains with wild-type microglia protects against many of these pathological changes. Together with the accompanying study by Chadarevian and colleagues

, our results indicate that the lifelong absence of microglia results in an age-related neurodegenerative condition that can be counteracted via transplantation of healthy microglia.