Didn't your competent? doctor start have you getting selenium a long time ago?
Somehow I doubt your doctor and hospital
has done one damn thing with this in 9 years and won't do a damn thing
now. Don't do anything with this until your doctor prescribes it. Will this selenium lower the risk of Parkinsons and Alzheimers? Why doesn't you doctor know the answer to that easy question?
Taken at normal doses, selenium does not usually have side effects. An overdose of selenium may cause bad breath, fever, and nausea, as well as liver, kidney and heart problems and other symptoms. At high enough levels, selenium could cause death.
selenium (9 posts to May 2015)
Selenium-containing compounds: a new hope for innovative treatments in Alzheimer’s disease and Parkinson’s disease
Keywords
Introduction
Selenium and seleno-compounds have been largely studied in diseases with distinct aetiologies and development stages, such as cancer and neurodegenerative diseases [1], [2], [3], [4], [5], [6]. With regards to the latter group, considerable research efforts are ongoing, driven by the hope of obtaining therapeutics that are less toxic and more effective than current treatments. Selenium has been reported to exert diametral effects on the central nervous system (CNS), showing both toxic and protective properties [7], [8]. Thus, several groups have focused on different strategies to incorporate selenium into bioactive compounds and small molecules [9].
Over the past 40 years, evidence in the scientific literature has demonstrated that small selenium-containing compounds represent good candidates in drug discovery, particularly because of their ability to counteract cancer development and cellular oxidation [10]. The design, synthesis and testing of bioactive molecules has grown exponentially, and the focus, at first limited to a few diseases, has been rapidly extended to a larger spectrum of pathologies.
Here, we provide a concise overview of the potential of selenium-containing compounds, which represent a growing field of investigation for treating neurodegenerative diseases. Specifically, we focus on two neurological disorders that represent an open question for both scientists and clinicians: Alzheimer’s disease (AD) and Parkinson’s disease (PD).
For AD, there has been interest in dissecting the molecular mechanisms involved in its onset to allow the development of new therapeutic strategies [11]. The mechanisms responsible for the decline of cognitive abilities, cytotoxicity, inflammation and the oxidative stress induced by amyloid-β (Aβ) aggregates, all typical hallmarks of AD, have been extensively dissected to identify specific molecular targets for the design of highly selective small molecules. In this frame, some seleno-compounds, alone or in combination with other molecules, have demonstrated efficacy against stress oxidation and cytotoxicity, as well as against tau tangles and Aβ aggregate accumulation (Figure 1) [12].
FIGURE 1. The accumulation of Aβ plaques in the extracellular compartment and of tau protein tangles within neuronal cells in AD.
In the case of PD, selenium derivatives have been tested both in vitro and in vivo for their ability to reduce neurotoxicity, cellular oxidation in the brain and the typical symptoms of the disease. Hence, selenium derivatives could represent a good strategy for new therapies [13].
Within this keynote review, we critically discuss recent findings in the field of selenium-based applications in neurological disorders, hand in hand with their relative targets.
More at link.
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