Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, December 14, 2024

Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke

 I'm sure your competent? doctor has been all over this subject for years! NO? So, you don't have a functioning stroke doctor, do you?

  • Senescence (7 posts to March 2015)
  • Senolytics (5 posts to March 2015)
  • senolytic drugs (1 post to July 2021)

    • Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke


    Zhihai Huang1,2
    , Peisheng Xu 3
    , David C. Hess1 and Quanguang Zhang
    *Correspondence:
    Quanguang Zhang
    qzhang@augusta.edu
    1 Department of Neurology, Medical College of Georgia, Augusta
    University, 1120 15th Street, Augusta, GA 30912, USA
    2 Department of Pharmacology, Toxicology and Neuroscience, Louisiana
    State University Health Sciences Center, 1501 Kings Highway, Shreveport,
    LA 71103, USA
    3 Department of Drug Discovery and Biomedical Sciences, College
    of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC
    29208, USA

    Abstract

    Traumatic brain injury (TBI) and stroke pose major health challenges, impacting millions of individuals globally. Once considered solely acute events, these neurological conditions are now recognized as enduring pathological processes with long-term consequences, including an increased susceptibility to neurodegeneration. However, effective strategies to counteract their devastating consequences are still lacking. Cellular senescence, marked by irreversible cell-cycle arrest, is emerging as a crucial factor in various neurodegenerative diseases. Recent research further reveals that cellular senescence may be a potential driver for secondary neurodegeneration following brain injury. Herein, we synthesize emerging evidence that TBI and stroke drive the accumulation of senescent cells in the brain. The rationale for targeting senescent cells as a therapeutic approach to combat neurodegeneration following TBI/stroke is outlined. From a translational perspective, we emphasize current knowledge and future directions of senolytic therapy for these neurological conditions.

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