Deans' stroke musings: Association between mean corpuscular volume and 3 month outcome in patients with acute ischemic stroke: a second analysis based on a prospective cohort study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, December 2, 2025

Association between mean corpuscular volume and 3 month outcome in patients with acute ischemic stroke: a second analysis based on a prospective cohort study

Since there was no attempt to say what interventions should occur based on this research, IT WAS TOTALLY FUCKING USELESS! Doesn't anyone in stroke know how to think about getting survivors recovered?

Association between mean corpuscular volume and 3 month outcome in patients with acute ischemic stroke: a second analysis based on a prospective cohort study

Zheng Lv^†

Yanrong Miao^†

Meiying Zhu

Fei Li^*

Department of Rehabilitation Medicine, Shenzhen Longgang Central Hospital, Shenzhen Ninth People’s Hospital, Guangzhou University of Chinese Medicine Shenzhen Clinical School of Medicine, Shenzhen, Guangdong, China

Introduction: Acute ischemic stroke is a major cause of global mortality and disability. This study aimed to investigate the association between mean corpuscular volume (MCV) and 3-month outcomes in acute ischemic stroke patients.

Methods: This study is a secondary analysis based on a prospective cohort study conducted at a single center in Korea from January 2010 to December 2016. The study included 1,906 acute ischemic stroke patients. The exposure variable was MCV measured within 24 hours of admission, and the outcome variable was the modified Rankin Scale (mRS) score at 3 months post-admission. Covariates included age, gender, body mass index, hemoglobin, hematocrit, liver function indicators, diabetes history, and stroke etiology.

Results: Piecewise linear regression analysis revealed a non-linear U‑shaped association of MCV on adverse outcomes, with a critical turning point at 92.1 fl. After full adjustment (Model 3), when MCV was below 92.1 fL, each 1 fL increase was associated with an 8% lower odds of poor 3-month outcome (OR = 0.92, 95% CI: 0.88–0.96, p = 0.0003). Conversely, when MCV exceeded 92.1 fL, each 1 fL increase was associated with a 4% higher odds of poor outcome (OR = 1.04, 95% CI: 1.00–1.08, p = 0.0391).

Conclusion: There was a U‑shaped association between MCV and three-month outcome in patients with acute ischemic stroke.