Deans' stroke musings: Severity of skin psoriasis linked to blood vessel inflammation, cardiovascular risk

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, October 9, 2015

Severity of skin psoriasis linked to blood vessel inflammation, cardiovascular risk

Be careful out there.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=156988&CultureCode=en
People with more psoriasis may also have more inflammation in theirblood vessels, according to research published in the American Heart Association journalArteriosclerosis, Thrombosis and Vascular Biology.
Psoriasis is a chronic inflammatory disease affecting about 3 percent of U.S. adults. It occurs when skin cells grow too quickly, resulting in thick white or red patches of skin.
Previous research suggests psoriasis may be linked with a higher risk of cardiac events and cardiovascular-related death. This may be the first study to examine whether psoriasis severity impacts inflammation in the blood vessels.
In the study, researchers analyzed 60 adults (average age 47) with psoriasis and 20 (average age 41) without psoriasis. All study participants were at low risk for cardiovascular disease based on a traditional risk assessment. They underwent a nuclear scan that measured blood vessel inflammation, and a dermatologist assessed the amount of psoriasis.
Researchers found:

Patients had psoriasis ranging from mild (only a few patches, less than 3 percent of the skin surface affected) to severe (when patches cover more than 10 percent of the skin surface).
Patients had high levels of inflammation in their blood vessels — even though they were at low risk for cardiovascular disease.
The most extensive forms of psoriasis were associated with a 51 percent increase in blood vessel inflammation.
The relationship between psoriasis and increased blood vessel inflammation didn’t change much after accounting for other heart disease risk factors.

“The most important observation we made was that the more psoriasis was on the skin, the more inflammation there was in the blood vessels,” said senior study author Nehal N. Mehta, M.D., M.S.C.E., a Lasker clinical investigator in the Cardiovascular and Pulmonary Branch of the National Heart, Lung, and Blood Institute in Bethesda, Maryland. “In other words, what we see on the outside is mirrored on the inside.”
The findings support the idea that the skin disease and cardiovascular disease may share an immune-related underlying mechanism, but doesn’t prove one causes the other.
“People who have psoriasis — particularly if it is severe — should be assessed by their doctor for cardiovascular risk factors, including diabetes, high cholesterol and obesity,” Mehta said. “They should also maintain an active lifestyle, avoid smoking and follow a balanced diet.”
Co-authors are Haley B. Naik, M.D., M.H.Sc.; Balaji Natarajan, M.D.; Elena Stansky, B.S.; Mark A. Ahlman, M.D.; Heather Teague, Ph.D.; Taufiq Salahuddin, B.S.; Qimin Ng, B.S.; Aditya A. Joshi, M.D.; Parasuram Krishnamoorthy, M.D.; Jenny Dave, M.S.; Shawn M. Rose, M.D., Ph.D.; Julia Doveikis, B.S.; Martin P. Playford, Ph.D.; Ronald B. Prussick, M.D.; Alison Ehrlich, M.D.; Mariana J. Kaplan, M.D.; Benjamin N. Lockshin, M.D.; and Joel M. Gelfand, M.D., M.S.C.E.
The NHLBI Intramural Research Program and National Psoriasis Foundation funded the study.
Additional Resources:

Researcher photo, heart attack animation, and heart and brain graphics are located in the right column of this release link http://newsroom.heart.org/news/severity-of-skin-psoriasis-linked-to-blood-vessel-inflammation-cardiovascular-risk?preview=9d1232c2cd4549625d357c593db8e09f
Follow AHA/ASA news on Twitter @HeartNews.
For updates and new science from JAHA, follow @JAHA_AHA.

http://newsroom.heart.org/news/severity-of-skin-psoriasis-linked-to-blood-vessel-inflammation-cardiovascular-risk?preview=9d1232c2cd4549625d357c593db8e09f

Full bibliographic informationSeverity of Psoriasis Associates With Aortic Vascular Inflammation Detected by FDG PET/CT and Neutrophil Activation in a Prospective Observational Study. (DOI: 10.1161/ATVBAHA.115.306460.)