I'm back and still as pissed off as ever. These people don't even know the correct problem to solve. You fucking idiots, cholesterol is not the problem, inflammation is, which grabs the cholesterol out of the bloodstream packing it into plaque. Learn about cause and effect and stop trying to force statins to be the only solution.
https://www.washingtonpost.com/news/to-your-health/wp/2016/04/03/statin-intolerance-is-real-researchers-find-but-another-more-expensive-drug-may-help/
Statins like Lipitor and its generics have revolutionized
cardiovascular care for nearly two decades as an effective, inexpensive
way to reduce LDL cholesterol, the so-called bad cholesterol in the
bloodstream.
Not everyone can take them, though; a
significant number of people complain of muscle pain, weakness and
cramping so severe that they discontinue the therapy even at the risk of
a heart attack or stroke. Their resistance to the medication has been
controversial, because in most cases there are no biomarkers for the
muscle problems individuals describe. Some researchers have speculated
that the problem is psychological, the "nocebo" effect of blaming the
medication for the pain.
But a study released Sunday shows
for the first time that statin intolerance is very real and that a
newer, different kind of drug can have a strong impact on these
patients' high cholesterol.
Researchers
found that 42.6 percent of people who had complained of muscle pain
while taking at least two different statins experienced the same
symptoms when given a statin during the study but had no ill effects
when administered a placebo. They were then able to reduce their LDL
cholesterol levels by more than half when given a PCSK9 inhibitor,
evolocumab, for 24 weeks, compared with just a 16.7 percent reduction on
ezetimibe, another medication.
The Food and Drug Administration
approved PCSK9 inhibitors last year, but only for small groups of
people, including those with an inherited disease that dramatically
elevates their LDL cholesterol levels.
"This problem of statin
intolerance is one of the most vexing problems for both patients and
physicians in cardiovascular medicine," Steven E. Nissen, chairman of
the Department of Cardiovascular Medicine at the Cleveland Clinic, said
in an interview. He said the new study, which he led, offers hope for
people who have not been able to take statins because of side effects.
The
research was unveiled Sunday at the American College of Cardiology's
annual conference and published simultaneously in the medical journal
JAMA. It was funded by Amgen, maker of evolocumab, an injectable PCSK9
inhibitor. Nissen has worked with many pharmaceutical companies to
determine the efficacy of heart therapies but requires the companies to
donate any payments to charity so that he receives no compensation or
tax breaks, according to a bio accompanying the study.
Heart
disease is the leading killer of Americans, and some 73 million people
in the United States have high LDL cholesterol, which can greatly
increase their cardiovascular risk. Millions of people take statins to
lower their risk. In 2013, the American College of Cardiology and the
American Heart Association released new treatment guidelines that would
substantially increase the number of people on statins.
Mary
Norine Walsh, vice president of the American College of Cardiology and
medical director of Heart Failure and Cardiac Transplantation at St.
Vincent Heart Center in Indianapolis, called the study "encouraging."
PCSK9 inhibitors, she added, are "going to be, possibly, an option for patients who are statin intolerant."
But
that may not happen for a while. In addition to requiring FDA approval,
the drugs are much more expensive -- from $10,000 to $15,000 a year.
And because evidence of statin intolerance is largely subjective,
insurance companies may balk until there are ways to more conclusively
prove that patients are unable to take the cheaper drugs.
The two therapies have not yet been compared against each other in a randomized, controlled study, Walsh noted.
In
Nissen's study, 491 people who were unable to tolerate various kinds or
doses of statins were given atorvastatin (Lipitor) or a placebo at 53
research sites around the world. Their ages ranged from 18 to 80, and
they had heart disease, high LDL cholesterol or other risk factors for
cardiovascular problems. Overall, 209 suffered side effects from the
statins and were put on either evolocumab or ezetemibe (Zetia).
The
PCSK9 inhibitor works by blocking a substance that hinders the liver's
ability to remove cholesterol from the blood. Ezetemibe, by contrast,
decreases cholesterol absorption in the small intestine.
The
monthly injections of the PCSK9 inhibitor proved far more effective
after 24 weeks, cutting patients' LDL cholesterol by an average of 52.8
percent, compared to 16.7 percent for the other drug.
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