Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 13993 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Deans' stroke musings
Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthateach daybecause there areeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group. My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Thursday, May 18, 2017
Constraint-Induced Movement Therapy for Chronic Hemiparesis: Neuroscience Evidence from Basic Laboratory Research and Quantitative Structural Brain MRI in Patients with Diverse Disabling Neurological Disorders (S43.003)
April 18, 2017
no. 16 Supplement
Objective: This presentation will review the basic neuroscience research origins and the effects of Constraint-Induced Movement therapy
(CIMT) on CNS structural neuroplasticity.
Experimental hemiparesis in primates overcame chronic limb nonuse by
applying specific behavioral neuroscience principles.
This research led to formulating a model for the
origination of sustained motor disability after neurological injury and
improvement by a novel therapeutic program. The
therapy became adapted to treating children and adults and termed CIMT.
the past 25 years multiple worldwide Randomized
Controlled Trials of CIMT enrolled nearly 2000 patients with diverse
disorders (stroke, cerebral palsy [CP], multiple
sclerosis [MS]), which indicated superiority of the approach against
therapies, with large treatment Effect Sizes and
sustained retention of improved spontaneous real-world use of the
limb. Ongoing research will describe basic and
clinical neuroimaging methods to explore the basis for the clinical
Basic neuroscience models of experimental limb nonuse in rodents that
had undergone adapted CIMT, which were followed
by histological studies. (2) Voxel-based
morphometry (VBM) of grey matter and Tract-based spatial statistics
(TBSS) of white
matter on structural brain MRI, which evaluated
neuroplastic changes after upper extremity CIMT.
Results: (1) CIMT in
rodents resulted in increased CNS axonal growth, synaptogenesis, and
neurogenesis compared to control interventions,
parallel with improved paretic limb use. (2) VBM
demonstrated profuse cortical and subcortical grey matter increase
CIMT for stroke, CP, and MS. TBSS indicated
significantly improved white matter integrity in MS. Neither structural
changes nor comparable improved paretic limb use
followed control interventions.
Conclusions: CIMT is
increasing worldwide practice to improve reduced real-world limb use in
chronic hemiparesis in diverse neurological
diseases and ages of patients. Structural CNS
changes following CIMT may support improved and extended functional use
Study Supported by: NIH, National MS Society
Disclosure: Dr. Mark has nothing to disclose. Dr. Taub has nothing to disclose.