Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Wednesday, May 17, 2017

Irish team unlock hidden triggers behind Alzheimer’s and Parkinson’s

You need this so demand prevention strategies from your doctor.
1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
3. A 20% chance in this research.   July 2013.

Parkinson’s Disease May Have Link to Stroke


 
https://www.siliconrepublic.com/innovation/alzheimers-parkinsons-breakthrough


A team of researchers from Trinity College Dublin believes it has unlocked the hidden secrets of how Alzheimer’s and Parkinson’s form in the brain.
Due to their damaging effects on the human brain – and friends and family – research into how neurodegenerative diseases develop has been extensive.
Despite the science industry gaining a better understanding over the past few decades, very little remains understood.

However, a research team from Trinity College Dublin’s CRANN nanoscience institute believes it has uncovered some of these mysteries, in the hope of one day being able to create an effective treatment for diseases such as Alzheimer’s and Parkinson’s.
In a paper published online, the team led by Prof Martin Hegner revealed that, for the first time, it has observed how proteins fold while being produced in real time.
The breakthrough was made by analysing individual ribosomes – complex molecules that use genetic information to assemble proteins.
Within each of our cells, there are approximately 7m of these ribosomes, just 20 nanometres in diameter, only determined by science as recently as 2000.
What makes them so important in research into neurodegenerative diseases is that the assembly of proteins in cells is crucial, as they must fold into complex shapes to perform as expected.

‘Pushes the boundaries of what is technically possible’

This protein synthesis had remained a mystery until this latest research, but Hegner and his team found that during this process, chains of amino acids called polypeptides fold into their final 3D structures.
This breakthrough is vital in the development of future medicines for the treatment of these neurodegenerative diseases, among others, and CRANN’s research has already caught the eye of some pharmaceutical companies.
“The ribosome translation machinery is a highly complex system, involving many different factors such as energy input, messenger RNA decoding, amino acids, as well as their relative movements and interactions,” said Hegner on his team’s research.
“Investigating this system at the single-molecule level required a highly ambitious and multifaceted approach that pushes the boundaries of what is technically possible.”

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