Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Wednesday, May 17, 2017

Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood

So whom is going to write up translational stroke protocols? I do want to know about the dragon's blood.
http://www.sciencedirect.com/science/article/pii/S0223523417303860

Highlights

Certain N-stilbenyl carboxamides promote neuroproliferation-type neurogenesis.
Certain N-stilbenyl carboxamides are effective at low doses of sub-milligram per kg.
N-Stilbenyl carboxamides are achiral and readily accessible.

Abstract

Reduction of hippocampal neurogenesis caused by aging and neurological disorders would impair neural circuits and result in memory loss. A new lead compound (N-trans-3′,4'-methylenedioxystilben-4-yl acetamide 27) has been discovered to efficiently stimulate adult rats' neurogenesis. In-depth structure-activity relationship studies proved the necessity of a stilbene scaffold that is absent in highly cytotoxic analogs such as chalcones and heteroaryl rings and inactive analogs such as diphenyl acetylene and diphenyl ethane, and validated the importance of an NH in the carboxamide and a methylenedioxy substituent on the benzene ring. Immunohistochemical staining and biochemical analysis indicate, in contrast to previously reported neuroprotective chemicals, N-stilbenyl carboxamides have extra capacity for neuroproliferation-type neurogenesis, thereby providing a foundation for improving the plasticity of the adult mammalian brain.

Graphical abstract

N-stilbenyl carboxamides are discovered as novel and efficient stimulators with the capacity of promoting neuroproliferation-type neurogenesis at sub-milligram per kg doses.
Image 1

Keywords

  • Neurogenesis;
  • Stilbene;
  • SAR;
  • Dragon's blood;
  • BrdU;
  • NeuN
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