Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Tuesday, May 23, 2017

Predicting brain atrophy from resting-state functional connectivity and structural connectivity in ischemic stroke (P5.297)

Who gives a shit about prediction you blithering idiots? What are you doing to prevent brain atrophy post stroke? What protocol is there for that?

  • April 27, 2017
    • Poster Session V
      • Stroke Recovery and Rehabilitation

  1. Michael D. Fox1
  1. Neurology vol. 88 no. 16 Supplement P5.297


Objective: To investigate whether resting-state functional connectivity MRI (rs-fcMRI) can predict brain atrophy caused by ischemic stroke, and whether this prediction is independent of structural connectivity from diffusion MRI (dMRI).
Background: A stroke in one location can have effects on remote but connected brain regions, including focal atrophy. dMRI has previously been shown to predict regional atrophy of connected brain regions. Improving the prediction of these remote effects may improve symptom localization, prognosis, and allow for individualized neurorehabilitation.
Design/Methods: 26 patients with acute ischemic stroke received anatomical MRI scans shortly after their stroke and then again at a later date (10.7±7.5 months). The change in volume (atrophy) of 116 automated anatomical labeling (AAL) regions was computed. Connectivity of each AAL region to the lesion location was assessed using rs-fcMRI from a large cohort of normal subjects (N = 98). For dMRI, connectivity was the percentage of tracks from the AAL region that passed through the lesion mask, as used in prior work. The lesioned areas themselves were excluded from analyses. Mixed-effects regression analyses of atrophy as outcome, with rs-fcMRI and/or dMRI values as fixed effects and individual patients as random effect were conducted.
Results: Rs-fcMRI with the lesion location was a significant predictor of remote atrophy (z = 4.03, p = 5.6e-05), whereas dMRI fell just short of significance (z = 1.70, p = .089). Regression analysis of atrophy including both rs-fcMRI and dMRI as predictors found a significant effect of rs-fcMRI (z = 3.78, p = 0.0002) but not dMRI (z = 0.98, p = 0.33).
Conclusions: Resting-state functional connectivity with the lesion location can predict atrophy of remote brain regions after ischemic stroke, independent of structural white-matter connectivity.
Study Supported by: M.D.F. was supported by the National Institutes of Health (R21 MH099196, K23 NS083741), Dystonia Medical Research Foundation, National Parkinson’s Foundation, and NFL Players Association. A.J. was supported by a Postdoctoral Fellowship from the Natural Sciences and Engineering Research Council of Canada (NSERC PDF 454617). A.D.B. was supported by 4K12HD027748-24.
Disclosure: Dr. Jannati has nothing to disclose. Dr. Boes has nothing to disclose. Dr. Horn has nothing to disclose. Dr. Pascual-Leone has received personal compensation for activities with Magstim, Nexstim, Neuronix, Starlab Neuroscience, Neuroelectrics, Axilum Robotics, and Neosync as a member of scientific advisory boards. Dr. Pascual-Leone has received personal compensation in an editorial capacity for the Annals of Neurology and the European Journal of Neuroscience. Dr. Kuceyeski has nothing to disclose. Dr. Fox has nothing to disclose.

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