Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Tuesday, May 23, 2017

Deep Sleep Helps the Brain Learn

What is your doctors sleep protocol? And does taking sleeping pills count as deep sleep? My sleep was ruined almost every morning by the blood vampires coming around at 7am to take blood from someone in my 4plex.
https://www.rdmag.com/article/2017/05/deep-sleep-helps-brain-learn?et_cid=5961225&

Scientists are closer to understanding why deep sleep is crucial for the brain’s ability to learn efficiently.
Researchers from the University of Zurich and the Swiss Federal Institute of Technology have discovered for the first time the causal context as to why deep sleep is crucial to the learning efficiency of the brain and developed a non-invasive method for modulating deep sleep in a targeted region of the brain.
“We have developed a method that lets us reduce the sleep depth in a certain part of the brain and therefore prove the causal connection between deep sleep and learning efficiency,” Reto Huber, professor at the University Children's Hospital Zurich and of Child and Adolescent Psychiatry at UZH, said in a statement.
The researchers focally perturbed deep sleep in the motor cortex, while investigating the consequences on behavioral and neurophysiological markers of neuroplasticity arising from dedicated motor practice. They discovered that the capacity to undergo neuroplastic changes is reduced by wakefulness but restored during unperturbed sleep.
A single sleepless night can lead to difficulty in mastering mental tasks the following day. While we are awake we receive constant impressions of the environment, where synapses—connections between the nerve cells—are excited and intensified at times.
Perpetual increases in synaptic strength would render the brain highly insensitive to new inputs due to neurons losing their ability to fire selectively and synapses could not be further potentiated—saturating neural plasticity. The need for cellular maintenance and the removal of potentially neurotoxic waste would be enhanced, causing an unsustainable level of energy consumption.
According to the study, when slow waves are selectively perturbed in motor cortex, the restorative process is markedly attenuated, showing that deep sleep is a requirement for maintaining sustainable learning efficiency.
The researchers examined six women and seven men, who had to master three different motoric tasks during the study.  The volunteers had their sleep manipulated at times while the researchers localized the part of the brain responsible for learning the finger movements they were tasked with for the control of motor skills.
The researchers were able to learn how the manipulation of deep sleep impacted the motoric learning tasks the next day.
The participants performed well in the morning after a deep sleep but struggled more as the day went on. After sleeping again, the participant’s efficiency increased.  However, after a manipulated sleep performance, difficulties in learning the finger movements was noticeably weaker.
“In the strongly excited region of the brain, learning efficiency was saturated and could no longer be changed, which inhibited the learning of motor skills,” Nicole Wenderoth, a professor in the Department of Health Sciences and Technology at the ETH Zurich, said in a statement. 
According to the study, there is a lack of causal evidence in humans due to the inability to sleep deprive one target area while keeping the natural sleep pattern intact.
“Many diseases manifest in sleep as well, such as epilepsy,” Huber said. “Using the new method, we hope to be able to manipulate those specific brain regions that are directly connected with the disease.”
The study was published in Nature Communications.   

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