Deans' stroke musings: Effectiveness of botulinum toxin for lower limbs spasticity after stroke: A systematic review and meta-analysis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, January 14, 2018

Effectiveness of botulinum toxin for lower limbs spasticity after stroke: A systematic review and meta-analysis

O fuck, another piece of lazy research suggesting further followup instead of coming up with stroke protocols, just kicking the can down the road and taking no responsibility for anything in stroke.
http://search.naric.com/research/rehab/redesign_record.cfm?search=2&type=all&criteria=J77358&phrase=no&rec=135295&article_source=Rehab&international=0&international_language=&international_location=
Topics in Stroke Rehabilitation , Volume 23(3) , Pgs. 217-223.

NARIC Accession Number: J77358. What's this?
ISSN: 1074-9357.
Author(s): Wu, Tao; Li, Jian; Song, Hai X.; Dong, Yan.
Publication Year: 2016.
Number of Pages: 7.
Abstract: Study evaluated the current evidence on the effectiveness of botulinum toxin (BTX) injection for lower-limb spasticity after stroke. Electronic databases were searched from their inception through week 23 of 2015 for randomized controlled trials (RCTs) comparing the clinical efficacy of BTX injection to placebo or conventional therapy on lower-limb spasticity after stroke. One thousand three hundred forty-three records were identified and among them, 7 RCTs (603 patients) were eligible for the final analysis. The authors constructed random effects models and calculated the mean difference (MD) or standardized mean difference for continuous outcomes. Analysis revealed a statistically significant decrease in muscle tone was observed at week 4 and week 12 after injection. Patients who received in BTX therapy were likely to have statistically significant increased Fugl-Meyer score compared to the control group at 24-weeks follow-up, with MD = 3.19. There was no difference in gait speed between two groups during whole follow-up period. In this meta-analysis, BTX showed more persistent clinical benefits in lower-limb spasticity and the Fugl-Meyer score than placebo in patients after stroke. These results suggest that BTX could be a useful and safe strategy for the treatment of lower-limb spasticity after stroke. Further investigation is required to determine the effectiveness of BTX injection for stroke patients with optimal timing and dose of intervention.
Descriptor Terms: DRUGS, LIMBS, LITERATURE REVIEWS, MUSCULAR IMPAIRMENTS, PHARMACOLOGY, SPASTICITY, STROKE.

Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Wu, Tao, Li, Jian, Song, Hai X., Dong, Yan. (2016). Effectiveness of botulinum toxin for lower limbs spasticity after stroke: A systematic review and meta-analysis. Topics in Stroke Rehabilitation , 23(3), Pgs. 217-223. Retrieved 1/14/2018, from REHABDATA database.