So fucking what if your predictions are correct? That just means you completely and totally failed in getting your patients 100% recovered. And why with that failure track record do you still have a job?
PREP2 Algorithm Predictions Are Correct at 2 Years Poststroke for Most Patients
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Abstract
Background. The PREP2 algorithm combines clinical and neurophysiological measures to predict upper-limb (UL) motor outcomes 3 months poststroke, using 4 prediction categories based on Action Research Arm Test (ARAT) scores. The algorithm was accurate at 3 months for 75% of participants in a previous validation study.
Objective. This study aimed to evaluate whether PREP2 predictions made at baseline are correct 2 years poststroke. We also assessed whether patients’ UL performance remained stable, improved, or worsened between 3 months and 2 years after stroke.
Methods. This is a follow-up study of 192 participants recruited and assessed in the original PREP2 validation study. Participants who completed assessments 3 months poststroke (n = 157) were invited to complete follow-up assessments at 2 years poststroke for the present study. UL outcomes were assessed with the ARAT, upper extremity Fugl-Meyer Scale, and Motor Activity Log. Results. A total of 86 participants completed 2-year follow-up assessments in this study. PREP2 predictions made at baseline were correct for 69/86 (80%) participants 2 years poststroke, and PREP2 UL outcome category was stable between 3 months and 2 years poststroke for 71/86 (83%). There was no difference in age, stroke severity, or comorbidities among patients whose category remained stable, improved, or deteriorated.
Conclusions. PREP2 algorithm predictions made within days of stroke are correct at both 3 months and 2 years poststroke for most patients. Further investigation may be useful to identify which patients are likely to improve, remain stable, or deteriorate between 3 months and 2 years.
Introduction
The PREP2 algorithm combines clinical and neurophysiological measures within a few days of stroke to make predictions for UL functional outcomes at 3 months poststroke (http://www.presto.auckland.ac.nz).4 Patients are predicted to achieve 1 of 4 functional UL outcome categories: Excellent, Good, Limited, or Poor. These UL functional outcome categories are based on ranges of scores on the Action Research Arm Test (ARAT), which were previously established through hypothesis free cluster analysis5 and subsequently refined (Table 1).4 Information that can be offered to patients in each predicted outcome category is provided in Table 1. This includes the expected level of UL function by 3 months poststroke and a suggested rehabilitation focus.
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Table 1. PREP2 Prediction Category Description and Suggested Rehabilitation Focus.


Figure 1.
The PREP2 algorithm. The SAFE score is the sum of the Medical Research
Council grades for Shoulder Abduction and Finger Extension, out of 5,
for a total SAFE score out of 10. MEP+ means that MEPs can be elicited
from the paretic extensor carpi radialis and/or first dorsal
interosseous muscles of the paretic upper limb (UL) using transcranial
magnetic stimulation. The algorithm predicts 1 of 4 possible UL
functional outcomes at 3 months poststroke. Each prediction category is
associated with rehabilitation goals that can be used to tailor UL
therapy.2
The colored dots represent, proportionally, PREP2 algorithm accuracy.
The dots are color coded based on the outcome category actually achieved
3 months poststroke (green, Excellent; blue, Good; orange, Limited;
red, Poor).
Abbreviations: MEP, motor evoked potential; NIHSS, National Institutes of Health Stroke Scale; SAFE, Shoulder Abduction and Finger Extension.
Abbreviations: MEP, motor evoked potential; NIHSS, National Institutes of Health Stroke Scale; SAFE, Shoulder Abduction and Finger Extension.
The aim of this study was to determine whether PREP2 predictions made within a few days poststroke were correct 2 years after stroke and determine whether UL performance improves, deteriorates, or remains stable between 3 months and 2 years after stroke. We hypothesized that PREP2 predictions made at baseline would be correct at 2 years poststroke and PREP2 outcome category and UL motor performance would remain stable between 3 months and 2 years after stroke.
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