You will need this, so DEMAND your doctor give you protocols to prevent dementia. You get to guess what a favorable lifestyle is or read the full text.
Your chances of getting dementia.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
JAMA. 2019;322(5):430-437. doi:10.1001/jama.2019.9879
Key PointsQuestion
Is a healthy lifestyle associated with lower risk of dementia, regardless of genetic risk?
Findings
In this retrospective cohort study that included 196 383
participants of European ancestry aged at least 60 years without
dementia at baseline, participants with a high genetic risk and
unfavorable lifestyle score had a statistically significant hazard ratio
for incident all-cause dementia of 2.83 compared with participants with
a low genetic risk and favorable lifestyle score. A favorable lifestyle
was associated with a lower risk of dementia and there was no
significant interaction between genetic risk and healthy lifestyle.
Meaning
A healthy lifestyle was associated with lower risk of dementia among participants with low or high genetic risk.
Importance
Genetic factors increase risk of dementia, but the extent to which this can be offset by lifestyle factors is unknown.
Objective
To investigate whether a healthy lifestyle is associated with lower risk of dementia regardless of genetic risk.
Design, Setting, and Participants
A retrospective cohort study that included adults of European
ancestry aged at least 60 years without cognitive impairment or dementia
at baseline. Participants joined the UK Biobank study from 2006 to 2010
and were followed up until 2016 or 2017.
Exposures
A polygenic risk score for dementia with low (lowest
quintile), intermediate (quintiles 2 to 4), and high (highest quintile)
risk categories and a weighted healthy lifestyle score, including no
current smoking, regular physical activity, healthy diet, and moderate
alcohol consumption, categorized into favorable, intermediate, and
unfavorable lifestyles.
Main Outcomes and Measures
Incident all-cause dementia, ascertained through hospital inpatient and death records.
Results
A total of 196 383 individuals (mean [SD] age, 64.1 [2.9]
years; 52.7% were women) were followed up for 1 545 433 person-years
(median [interquartile range] follow-up, 8.0 [7.4-8.6] years). Overall,
68.1% of participants followed a favorable lifestyle, 23.6% followed an
intermediate lifestyle, and 8.2% followed an unfavorable lifestyle.
Twenty percent had high polygenic risk scores, 60% had intermediate risk
scores, and 20% had low risk scores. Of the participants with high
genetic risk, 1.23% (95% CI, 1.13%-1.35%) developed dementia compared
with 0.63% (95% CI, 0.56%-0.71%) of the participants with low genetic
risk (adjusted hazard ratio, 1.91 [95% CI, 1.64-2.23]). Of the
participants with a high genetic risk and unfavorable lifestyle, 1.78%
(95% CI, 1.38%-2.28%) developed dementia compared with 0.56% (95% CI,
0.48%-0.66%) of participants with low genetic risk and favorable
lifestyle (hazard ratio, 2.83 [95% CI, 2.09-3.83]). There was no
significant interaction between genetic risk and lifestyle factors (P = .99).
Among participants with high genetic risk, 1.13% (95% CI, 1.01%-1.26%)
of those with a favorable lifestyle developed dementia compared with
1.78% (95% CI, 1.38%-2.28%) with an unfavorable lifestyle (hazard ratio,
0.68 [95% CI, 0.51-0.90]).
Conclusions and Relevance
Among older adults without cognitive impairment or dementia,
both an unfavorable lifestyle and high genetic risk were significantly
associated with higher dementia risk. A favorable lifestyle was
associated with a lower dementia risk among participants with high
genetic risk.
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