Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial

 

So we still have NO FUCKING CLUE what a blood pressure management protocol is. Hope you don't mind dying because of the cesspools of incompetence of the complete stroke medical world.  Unless YOU hold your stroke hospital's feet to the fire you are allowing your children and grandchildren to die or become disabled.

And with no measurement of 100% recovery they are not even trying to solve stroke.

Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial

Mohammad Anadani

,

Benjamin Maïer

,

Simon Escalard

,

Julien Labreuche

,

Adam de Havenon

,

Candice Sabben

,

Bertrand Lapergue

,

Benjamin Gory

,

Sebastien Richard

,

Igor Sibon

,

Jean-Philippe Desilles

, … See all authors

and of behalf the BP-TARGET Study Group

Originally published3 Feb 2022https://doi.org/10.1161/STROKEAHA.121.036701Stroke. 2022;0:STROKEAHA.121.036701

Abstract

Background and Purpose:

To assess the association between systolic blood pressure change (ΔSBP) at different time intervals after successful reperfusion(Not 100% recovery) with radiographic and clinical outcomes.

Methods:

This is a post hoc analysis of the BP-TARGET multicenter trial (Blood Pressure Target in Acute Stroke to Reduce Hemorrhage After Endovascular Therapy). ΔSBP was defined as end of procedure SBP minus mean SBP at different time intervals (15–60 minutes, 1–6 hours, and 6–24 hours postprocedure). The primary outcome was the poor functional outcome (90-day modified Rankin Scale score 3–6).

Results:

We included a total of 267 patients (130 in the intensive treatment group). Compared with patients with favorable outcome, patients with poor outcome had lower ΔSBP (less SBP reduction) at all times intervals. After adjusting for potential confounders including baseline SBP, both ΔSBP_15–60M and ΔSBP_6–24H were associated with lower odds of poor outcome (adjusted odds ratio per 5 mm Hg SBP reduction, 0.89 [95% CI, 0.81–0.99], and adjusted odds ratio 0.82 [95% CI, 0.73–0.92], respectively). Concerning safety outcomes, patients with intraparenchymal hemorrhage had lower ΔSBP at all time intervals. ΔSBP_15–60M was associated with lower odds of any intraparenchymal hemorrhage (adjusted odds ratio per 5 mm Hg SBP reduction 0.91 [95% CI, 0.83–0.99]). Conversely, ΔSBP was not associated with mortality or neurological deterioration at any time interval.

Conclusions:

After successful reperfusion, ΔSBP had a linear relationship with poor outcome and the risk of poor outcome was higher with less reduction from the baseline SBP.

REGISTRATION:

URL: https://www.clinicaltrials.gov; Unique identifier: NCT03160677.

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