Deans' stroke musings: Investigating the Neuroprotective Effects of Cannabinoids and Insulin-like Growth Factors on Glia with Induced Inflammation

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, June 18, 2022

Investigating the Neuroprotective Effects of Cannabinoids and Insulin-like Growth Factors on Glia with Induced Inflammation

Yeah this is for TBI, but your doctor should have enough functioning brain cells to be able to apply it to stroke.

Investigating the Neuroprotective Effects of Cannabinoids and Insulin-like Growth Factors on Glia with Induced Inflammation

William S. Dodd,1 Eric J. Panther,1 Kevin Pierre,1 Jairo S. Hernandez,1 Devan Patel,2 Brandon LuckeWold1,* 1. Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL 2. Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY * Correspondence to: Brandon Lucke-Wold, MD, PhhD Lillian S. Wells Department of Neurosurgery 1505 SW Archer Rd Gainesville, FL 32608 brandon.lucke-wold@neurosurgery.ufl.edu

Abstract Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. The full extent of secondary brain injury is still being intensely investigated; however, it is now clear that neurotrauma can incite chronic neurodegenerative processes. Chronic traumatic encephalopathy, Parkinson’s disease, and many other neurodegenerative syndromes have all been associated with a history of traumatic brain injury. The complex nature of these pathologies can make clinical assessment, diagnosis, and treatment challenging. The goal of this review is to provide a concise appraisal of the literature with focus on emerging strategies to improve clinical outcomes. First, we review the pathways involved in the pathogenesis of neurotrauma-related neurodegeneration and discuss the clinical implications of this rapidly evolving field. Next, because clinical evaluation and neuroimaging are essential to the diagnosis and management of neurodegenerative diseases, we analyze the clinical investigations that are transforming these areas of research. Finally, we briefly review some of the preclinical therapies that have shown the most promise in improving outcomes after neurotrauma