Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 23, 2022

Reproductive History Linked to Later Stroke Risk

This is useless information until there are protocols that prevent this stroke risk. Totally incomplete research. 

Reproductive History Linked to Later Stroke Risk

Infertility, stillbirth, miscarriage may increase stroke risk, analysis of eight studies suggests

by Elizabeth Short, Editorial Intern, MedPage Today

A photo of a female radiologist in her office monitoring an MRI scan of her female patient’s brain.

A history of infertility, recurrent miscarriage, or stillbirth may be a risk factor for stroke later in life, according to an analysis of eight prospective cohort studies.

Among over 600,000 women, infertility was associated with an increased risk of non-fatal stroke (HR 1.14, 95% CI 1.08-1.20), while a history of at least three miscarriages was associated with higher risks of both non-fatal stroke (HR 1.35, 95% CI 1.27-1.44) and fatal stroke (HR 1.82, 95% CI 1.58-2.10), reported Gita Mishra, PhD, of the University of Queensland in Australia, and colleagues.

Furthermore, those who experienced a stillbirth were at a 31% higher risk of non-fatal stroke, and those who had a history of recurrent stillbirth were at a 26% higher risk of fatal stroke, they noted in The BMJ.

"A history of recurrent miscarriages and death or loss of a baby before or during birth could be considered a female specific risk factor for stroke, with differences in risk according to stroke subtypes," Mishra and team concluded. "These findings could contribute to improved monitoring and stroke prevention for women with such a history."

Analyses by subtypes of non-fatal stroke showed infertility was associated with an increased risk of ischemic stroke (HR 1.15, 95% CI 1.07-1.23), while women with recurrent miscarriage were more likely to experience ischemic and hemorrhagic stroke versus women without miscarriage (HR 1.37, 95% CI 1.23-1.53, and HR 1.41, 95% CI 1.08-1.84, respectively).

As for fatal stroke, women with recurrent miscarriages were more likely to experience ischemic and hemorrhagic fatal stroke (HR 1.83, 95% CI 1.39-2.41, and HR 1.84, 95% CI 1.39-2.44, respectively), and those with recurrent stillbirth were more likely to have hemorrhagic fatal stroke (HR 1.44, 95% CI 1.35-1.53).

Mishra and team noted that the link between infertility and increased stroke risk may be due to disorders such as polycystic ovary syndrome and premature ovarian insufficiency, while endothelial dysfunction may explain the increased risk of stroke for women with a history of recurrent stillbirth or miscarriage.

For this analysis, Mishra and colleagues analyzed data on 618,851 women ages 32 to 73 from eight studies from seven countries -- China, Sweden, the Netherlands, the U.K., Japan, Australia, and the U.S. -- as part of the InterLACE (International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events) consortium. Of the included women, 275,863 had data on fatal and non-fatal stroke: 9,265 (2.8%) experienced a non-fatal stroke and 4,003 (0.7%) experienced a fatal stroke.

Median follow-up was 13 years after a non-fatal stroke and 9.4 years after a fatal stroke. Average ages at the time of first non-fatal stroke and fatal stroke were 62 and 71.

Of the included women, 17.2% experienced infertility, 16.6% experienced miscarriage, and 4.6% experienced stillbirth.

There were several limitations to this analysis, the authors acknowledged. Since data on infertility, miscarriage, and stillbirth were collected from questionnaires, recall bias is possible. Furthermore, while most models adjusted for certain comorbidities, others, such as endometriosis, thyroid disorders, and pelvic inflammatory disease, were not available in all studies.

Disclosures

This study was funded by the Australian National Health and Medical Research Council Centres of Research Excellence.

The study authors reported no conflicts of interest.

Primary Source

The BMJ

Source Reference: Liang C, et al "Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618851 women" BMJ 2022; DOI: 10.1136/bmj-2022-070603.

 
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