Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, November 11, 2022

Effects of curcumin, quercetin, and their combinations on neurodegeneration and motor impairment in rotenone-induced Parkinson's disease in rats

Don't do this, only been tested in rats. Maybe 50 years from now our researchers will have something, hope you're still alive by then. 

Your risk of Parkinsons here:

Parkinson’s Disease May Have Link to Stroke March 2017

The latest here:

 Effects of curcumin, quercetin, and their combinations on neurodegeneration and motor impairment in rotenone-induced Parkinson's disease in rats

Mehak Lard
M. M. College of Pharmacy, M. M. (Deemed to be University)
Shweta deol
M. M. College of Pharmacy, M. M. (Deemed to be University)
Meenakshi Dhanawat
M. M. College of Pharmacy, M. M. (Deemed to be University)
Dinesh Mehta
M. M. College of Pharmacy, M. M. (Deemed to be University)
Rina Das
M. M. College of Pharmacy, M. M. (Deemed to be University)
Sumeet Gupta ( sumeetgupta25@gmail.com )
M. M. College of Pharmacy, M. M. (Deemed to be University)
Mohamed A. Morsy
King Faisal University
Anroop B. Nair
King Faisal University
Asmaa. I. Matouk
Minia University
Nidhi Gupta
M. M. College of Pharmacy, M. M. (Deemed to be University)
Research Article
Keywords: Parkinson’s disease, curcumin, quercetin,behavioral activity, motor activity, dopamine
Posted Date: November 7th, 2022

Abstract

Background

Parkinson’s disease (PD) is associated with motor and behavioral dysfunctions. Mitochondrial damage, increased oxidative stress, and the formation of Lewy bodies by misfolded proteins are major pathways for the development of PD. Using antioxidants could delay neurodegeneration in parkinsonism and improve the symptoms. We investigated the neuroprotective effects of quercetin, curcumin, and their combination on the rotenone-induced parkinsonism model.

Methods

PDwas induced by administration of rotenone 2mg/kg/day for 14 days in rats. Curcumin (100, 150, and 200 mg/kg), quercetin (30, 40, and 50 mg/kg),or their combination were given orally for 14 days concurrently with rotenone and for additional 14 days. On the 28th and 29th days, behavioral and histological studies were carried out.

Results

In the rotenone-induced parkinsonism model, curcumin and quercetin dose-dependently improved locomotor activity, motor coordination, and mobility. Also, they increased dopamine levels and mitigated the neural damage induced by rotenone.

Conclusion

Both curcumin and quercetin have neuroprotective effects against parkinsonism. The combination of curcumin and quercetin has more favorable effects than usingeither drug alone.

 

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