Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, November 21, 2022

Functional MRI and ApoE4 genotype for predicting cognitive decline in amyloid-positive individuals

 What are the next steps to prevent this cognitive decline? No next steps, I'd fire all of you. Useless.

Functional MRI and ApoE4 genotype for predicting cognitive decline in amyloid-positive individuals

Abstract

Background:

In light of advancements in machine learning techniques, many studies have implemented machine learning approaches combined with data measures to predict and classify Alzheimer’s disease. Studies that predicted cognitive status with longitudinal follow-up of amyloid-positive individuals remain scarce, however.

Objective:

We developed models based on voxel-wise functional connectivity (FC) density mapping and the presence of the ApoE4 genotype to predict whether amyloid-positive individuals would experience cognitive decline after 1 year.

Methods:

We divided 122 participants into cognitive decline and stable cognition groups based on the participants’ change rates in Mini-Mental State Examination scores. In addition, we included 68 participants from Alzheimer’s Disease Neuroimaging Initiative (ADNI) database as an external validation data set. Subsequently, we developed two classification models: the first model included 99 voxels, and the second model included 99 voxels and the ApoE4 genotype as features to train the models by Wide Neural Network algorithm with fivefold cross-validation and to predict the classes in the hold-out test and ADNI data sets.

Results:

The results revealed that both models demonstrated high accuracy in classifying the two groups in the hold-out test data set. The model for FC demonstrated good performance, with a mean F1-score of 0.86. The model for FC combined with the ApoE4 genotype achieved superior performance, with a mean F1-score of 0.90. In the ADNI data set, the two models demonstrated stable performances, with mean F1-scores of 0.77 in the first and second models.

Conclusion:

Our findings suggest that the proposed models exhibited promising accuracy for predicting cognitive status after 1 year in amyloid-positive individuals. Notably, the combination of FC and the ApoE4 genotype increased prediction accuracy. These findings can assist clinicians in predicting changes in cognitive status in individuals with a high risk of Alzheimer’s disease and can assist future studies in developing precise treatment and prevention strategies.

No comments:

Post a Comment