Deans' stroke musings: Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, May 31, 2025

Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors

So you described a problem; WHAT THE FUCK IS THE SOLUTION? No solution, useless research, I'd fire you all.
Very similar to this useless research in September 2022:
Association between neutrophil percentage-to-albumin ratio and 3-month functional outcome in acute ischemic stroke patients with reperfusion therapy

The latest here:

Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors

Jie Huang1, Xiaowei Zhang2, Luyao Ding1, Jiaxiang Yu3 and Mingshen Lin2*

1Department of Cardiology, Lishui Municipal Central Hospital, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China

2Department of Clinical Laboratory, Lishui Municipal Central Hospital, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China

3Department of Emergency Medicine, Lishui Municipal Central Hospital, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China

Edited by

Hipólito Nzwalo, University of Algarve, Portugal

Reviewed by

Yahia Imam, Hamad Medical Corporation, Qatar

Sennur Delibas Kati, Antalya Training and Research Hospital, Türkiye

*Correspondence

Mingshen Lin, linmingshen@wmu.edu.cn

Received 14 April 2025

Accepted 12 May 2025

Published 30 May 2025

Citation

Huang J, Zhang X, Ding L, Yu J and Lin M (2025) Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors. Front. Aging Neurosci. 17:1611289. doi: 10.3389/fnagi.2025.1611289

Background: The neutrophil-percentage-to-albumin ratio (NPAR) functions as an integrative marker representing inflammatory response and nutritional health. However, its association with mortality in elderly stroke survivors has not been explored.

Methods: This cohort study analyzed data from 1,026 elderly stroke survivors in the National Health and Nutrition Examination Survey (NHANES, 1999-2018). The association of NPAR with mortality was analyzed using Cox proportional hazards regression, restricted cubic splines (RCS), Kaplan-Meier survival analysis, and time-dependent receiver operating characteristic (ROC) curves. Subgroup analyses and interaction tests were also performed.

Results: During the 6.65-year median follow-up, elevated NPAR showed independent associations with increased all-cause and cardiovascular mortality. Quartile-based analysis revealed 69 and 87% greater mortality hazards for the highest versus lowest NPAR groups, respectively. RCS analysis revealed a non-linear threshold effect at NPAR = 14.5, beyond which the risk of all-cause mortality increased sharply. NPAR demonstrated stable predictive accuracy, with time-dependent AUC ranging from 0.664 to 0.607 for all-cause mortality and 0.652-0.609 for cardiovascular mortality over 3-10 years. Subgroup analyses confirmed consistency across different sex, BMI, lifestyle habits, and comorbidity categories.

Conclusion: This study underscores a strong positive correlation between NPAR and prognosis in older adult stroke survivors in the United States, indicating its potential as a novel biomarker for prognostic assessment.