Deans' stroke musings: Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, May 26, 2025

Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review

Ask your competent? doctor how this will help stroke researchers get survivors recovered. If your doctor can't intelligently discuss this, you DON'T have a functioning stroke doctor! RUN AWAY!

Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review

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https://doi.org/10.1016/j.ijbiomac.2025.144636

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Abstract

In the last two decades, different routes of administration have been explored for the treatment of central nervous system (CNS) disorders, involving biomolecules and drugs. Among them, transmucosal route is gaining particular interest, due to its low toxicity in chronic treatments, as well as high and rapid drug absorption, making it suitable for systemic delivery of various drugs. Indeed, it allows an easy bypass of the blood-brain barrier by using the olfactory region, promoting a direct drug delivery to the brain. Despite its advantages, some side effects like nasal irritation and rapid drainage remain relevant.

Recent scientific studies are focusing on the design of mucoadhesive carriers to enhance drug residence time on the mucosa and providing sustained release. Hyaluronic acid (HA) is emerging as a valid solution for nasal delivery, with potential in treating CNS disorders. The main driving idea of this narrative review is to present the state of art on gels and micro/nanoparticles based on HA functionalized with natural extracts for treating the CNS via the nasal route. Future research aims to address existing challenges to improve their formulations for effective CNS delivery.