Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, May 22, 2025

Sitting for Hours May Shrink the Brain

 

Sedentary time wouldn't exist if you had 100% RECOVERY PROTOCOLS! If you can't figure that out; GET THE HELL OUT OF STROKE!

Your competent doctor should have solved this problem a long time ago!

Sitting for Hours May Shrink the Brain

Summary: Prolonged sedentary behavior in adults over 50 is linked to cognitive decline and brain shrinkage in regions vulnerable to Alzheimer’s disease. Even among those who exercise regularly, spending more time sitting was associated with worse cognitive outcomes.

The effect was strongest in individuals carrying the APOE-e4 gene, a major genetic risk factor for Alzheimer’s. These findings suggest that breaking up sedentary time throughout the day may be a key strategy for protecting brain health and reducing Alzheimer’s risk, especially in genetically vulnerable individuals.

Key Facts:

  • Independent of Exercise: More sitting led to cognitive decline even in regular exercisers.
  • Genetic Risk Factor: Effects were more pronounced in APOE-e4 carriers.
  • Brain Impact: Sedentary behavior was associated with brain shrinkage over 7 years.

Source: Vanderbilt University

Over 6 million Americans are impacted by Alzheimer’s disease, and researchers from Vanderbilt University Medical Center and the University of Pittsburgh are discovering how lifestyle habits can impact the likelihood of developing the disease.

According to a new research study published in Alzheimer’s & Dementia, researchers found that increased sedentary behavior, time spent sitting or lying down, in aging adults was associated with worse cognition and brain shrinkage in areas related to risk for developing Alzheimer’s disease.

This shows an older man sitting and brains.
These conclusions were stronger in participants who carried the APOE-e4 allele, a genetic risk factor for Alzheimer’s disease, suggesting that reducing sedentary time may be especially important for older adults who are at increased genetic risk for Alzheimer’s disease. Credit: Neuroscience News

The research study was led by Marissa Gogniat, PhD, assistant professor of Neurology at Pitt and former postdoctoral fellow at the Vanderbilt Memory and Alzheimer’s Center, and co-authored by Angela Jefferson, PhD, professor of Neurology and founding director of the Vanderbilt Memory and Alzheimer’s Center at VUMC.

The team of researchers examined the relationship between sedentary behavior and neurodegeneration among 404 adults age 50 and older.

Study participants wore a watch that measured their activity continuously over the span of a week. Their sedentary time was then related to their cognitive performance and brain scans captured over a seven-year follow-up period. 

Participants who spent more time sedentary were more likely to experience cognitive decline and neurodegenerative changes regardless of how much they exercised. 

These conclusions were stronger in participants who carried the APOE-e4 allele, a genetic risk factor for Alzheimer’s disease, suggesting that reducing sedentary time may be especially important for older adults who are at increased genetic risk for Alzheimer’s disease.

“Reducing your risk for Alzheimer’s disease is not just about working out once a day,” said Gogniat. “Minimizing the time spent sitting, even if you do exercise daily, reduces the likelihood of developing Alzheimer’s disease.”

“It is critical to study lifestyle choices and the impact they have on brain health as we age,” said Jefferson, who holds the Herbert O. and Vineta Christopher Directorship. 

“Our study showed that reducing sitting time could be a promising strategy for preventing neurodegeneration and subsequent cognitive decline.

“This research highlights the importance of reducing sitting time, particularly among aging adults at increased genetic risk for Alzheimer’s disease. It is critical to our brain health to take breaks from sitting throughout the day and move around to increase our active time.”

Funding: The study was funded by the Alzheimer’s Association and the National Institute on Aging.

About this sedentary behavior and Alzheimer’s disease research news

Author: Craig Boerner
Source: Vanderbilt University
Contact: Craig Boerner – Vanderbilt University
Image: The image is credited to Neuroscience News

Original Research: Open access.
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity” by Marissa Gogniat et al. Alzheimer’s & Dementia

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