More hyperacute trials needed, get your doctor to request these be setup and run.
http://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm2012166a.html
Glibenclamide is neuroprotective against cerebral ischemia in rats. We
studied whether glibenclamide enhances long-term brain repair and
improves behavioral recovery after stroke. Adult male Wistar rats were
subjected to transient middle cerebral artery occlusion (MCAO) for 90 minutes. A low dose of glibenclamide (total 0.6 μg) was administered intravenously 6, 12, and 24 hours
after reperfusion. We assessed behavioral outcome during a 30-day
follow-up and animals were perfused for histological evaluation. In
vitro specific binding of glibenclamide to microglia increased after
pro-inflammatory stimuli. In vivo glibenclamide was associated with
increased migration of doublecortin-positive cells in the striatum
toward the ischemic lesion 72 hours
after MCAO, and reactive microglia expressed sulfonylurea receptor 1
(SUR1) and Kir6.2 in the medial striatum. One month after MCAO,
glibenclamide was also associated with increased number of NeuN-positive
and 5-bromo-2-deoxyuridine-positive neurons in the cortex and
hippocampus, and enhanced angiogenesis in the hippocampus. Consequently,
glibenclamide-treated MCAO rats showed improved performance in the
limb-placing test on postoperative days 22 to 29, and in the cylinder
and water-maze test on postoperative day 29. Therefore, acute blockade
of SUR1 by glibenclamide enhanced long-term brain repair in MCAO rats,
which was associated with improved behavioral outcome.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,972 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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