http://www.sciencedirect.com/science/article/pii/S0308814612016561
Abstract
Fish
oil during early postnatal period may modulate the impact of oxidative
stress in the developing brain and thus improve memory and cognitive
behavior. This study investigated the impacts of docosahexaenoic acid
(DHA, C22:6, n-3) and/or phosphatidylserine (PS) on antioxidant
activities in vitro, and the beneficial effects of feeding with
DHA and/or PS on antioxidant activities in brain and liver tissues and
on the cognitive functions of the developing brain. Results indicated
that DHA and/or PS significantly enhanced antioxidant activities and
increased cell viabilities in vitro. Feeding with DHA and/or PS
supplementation not only significantly improved escape latency of
animals, but it also improved the oxidative parameters in the brain,
enhanced glutathione peroxidase activity as well as reduced nitric
mono-oxide levels in the liver. DHA and PS may serve to protect cells
from oxidative stress and further improve learning and memory ability in vivo.
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