Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,286 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Saturday, November 24, 2012
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
During neurogenesis, neural stem/progenitor cells (NPCs)
undergo an irreversible fate transition to become neurons. The Notch
pathway is important for this process, and repression of Notch-dependent
Hes genes is essential for triggering differentiation. However,
Notch signaling often remains active throughout neuronal
differentiation, implying a change in the transcriptional responsiveness
to Notch during the neurogenic transition. We identified Bcl6,
an oncogene, as encoding a proneurogenic factor that is required for
proper neurogenesis of the mouse cerebral cortex. BCL6 promoted the
neurogenic conversion by switching the composition of Notch-dependent
transcriptional complexes at the Hes5 promoter. BCL6 triggered exclusion of the co-activator Mastermind-like 1 and recruitment of the NAD+-dependent deacetylase Sirt1, which was required for BCL6-dependent neurogenesis. The resulting epigenetic silencing of Hes5
led to neuronal differentiation despite active Notch signaling. Our
findings suggest a role for BCL6 in neurogenesis and uncover
Notch-BCL6-Sirt1 interactions that may affect other aspects of
physiology and disease.
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