Deans' stroke musings: Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, January 22, 2013

Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke

Spontaneous recovery at the same time so impossible to tell what caused the results. Double blind trials needed.
http://scholar.google.com/scholar_url?hl=en&q=http://downloads.hindawi.com/journals/mi/aip/512978.pdf&sa=X&scisig=AAGBfm23r3UvM3T4tyggnkDX4Tcmy7nG_g&oi=scholaralrt
Abstract
Several studies have provided evidence with regards to the neuroprotection benefits of hyperbaric oxygen (HBO) therapy in cases of stroke. HBO also promotes bone marrow stem cells (BMSCs) proliferation and mobilization. This study investigates the influence of HBO therapy on the migration of BMSCs, neurogenesis, gliosis, and inflammation after transient ischemic stroke. Rats that sustained one hour of transient middle cerebral artery occlusion (MCAO) were treated with HBO 15 times within 3 weeks or HBO two times within two days. The results were examined using a behavior test (modified neurological severity score, mNSS) and immunohistochemistry staining on CD34-DAPI, BrdU-NeuN, BrdU-GFAP were used to evaluate the effects of HBO therapy on migration of bone marrow stem cells, neurogenesis and gliosis, as well as expression of neurotrophic factors were also evaluated. HBO significantly attenuated ischemic injury of transient MCAO. There was a lower mNSS score in the three weeks HBO group (6.2 in day 21), when compared with the two days HBO group (9.75 in day 21). This demonstrated that 3 weeks of HBO treatment had a significantly better neurological outcome than a two days HBO course, suggesting the dose-dependent effect of HBO therapy. Mobilization of BMSCs to an ischemic area was more improved in long course HBO treatments but not by short course treatments, suggesting that the duration of therapy is crucial for promoting the homing of BMSCs to ischemic brain by HBO therapies. HBO also can stimulate expression of trophic factors and improve neurogenesis and gliosis. These effects may help neuronal repair after ischemic stroke and increasing the course of HBO therapy from 2 days to 3 weeks might enhance therapeutic effects on ischemic stroke.