http://www.neurology.org/content/68/8/563.short
Abstract
Objective: To determine if levels of serum estradiol and testosterone can predict stroke in a population-based sample of elderly men.
Methods: Serum 17β
estradiol and testosterone were measured in 2,197 men aged 71 to 93
years who participated in the Honolulu-Asia
Aging Study from 1991 to 1993. All were free of
prevalent stroke, coronary heart disease, and cancer. Participants were
followed
to the end of 1998 for thromboembolic and
hemorrhagic events.
Results: During the
course of follow-up, 124 men developed a stroke (9.1/1,000
person-years). After age adjustment, men in the top
quintile of serum estradiol (≥125 pmol/L [34.1
pg/mL]) experienced a twofold excess risk of stroke vs men whose
estradiol
levels were lower (14.8 vs 7.3/1,000 person-years, p
< 0.001). Among the lower quintiles, there were little differences
in the risk of stroke. Findings were also significant
and comparable for bioavailable estradiol and for
thromboembolic and hemorrhagic events. After additional adjustment for
hypertension,
diabetes, adiposity, cholesterol concentrations,
atrial fibrillation, and other characteristics, men in the top quintile
of
serum estradiol continued to have a higher risk of
stroke vs those whose estradiol levels were lower (relative hazards =
2.2;
95% CI = 1.5 to 3.4, p < 0.001). Testosterone was not related to the risk of stroke.
Conclusions: High levels of serum estradiol may be associated with an elevated risk of stroke in elderly men.
No comments:
Post a Comment