Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, November 12, 2013

Parental longevity is associated with cognition and brain ageing in middle-aged offspring

So since my Mom at 95 still living at home and doing good, dad died at 91 with Parkinsons dementia, at least Parkinsons is not genetic, Maybe my  dementia chances are not that great.
But after your stroke how much is your doctor working on preventing dementia in you? They've done nothing for your recovery, are they at least working on preventing your dementia?
Parental longevity is associated with cognition and brain ageing in middle-aged offspring

  1. Rhoda Au2,4
+ Author Affiliations
  1. 1Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
  2. 2NHLBI's Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA, USA
  3. 3Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
  4. 4Department of Neurology, Boston University School of Medicine, Boston, MA, USA
  5. 5University of California at Davis, Sacramento, CA, USA
  1. Address correspondence to: J. M. Murabito. Tel: (+1) 5089353461; Fax: (+1) 5086261262. Email: murabito@bu.edu
  • Received April 17, 2013.
  • Accepted August 16, 2013.

Abstract

Background: offspring of long-lived individuals have lower risk for dementia. We examined the relation between parental longevity and cognition and subclinical markers of brain ageing in community-dwelling adult offspring.
Methods: offspring participants with both parents in the Framingham Heart Study, aged ≥55 years and dementia-free underwent baseline and repeat neuropsychological (NP) testing and brain magnetic resonance imaging (MRI). Parental longevity was defined as having at least one parent survive to age ≥85 years. To test the association between parental longevity and measures of cognition and brain volumes, we used multivariable linear and logistic regression adjusting for age, sex, education and time to NP testing or brain MRI.
Results: of 728 offspring (mean age 66 years, 54% women), 407 (56%) had ≥1 parent achieve longevity. In cross-sectional analysis, parental longevity was associated with better scores on attention (beta 0.21 ± 0.08, P = 0.006) and a lower odds of extensive white matter hyperintensity on brain MRI (odds ratio 0.59, 95% CI: 0.38, 0.92, P = 0.019). The association with white matter hyperintensity was no longer significant in models adjusted for cardiovascular risk factors and disease. In longitudinal analysis (6.7 ± 1.7 years later), offspring with parental longevity had slower decline in attention (0.18 ± 0.08, P = 0.038), executive function (beta 0.19 ± 0.09, P = 0.031) and visual memory (beta −0.18 ± 0.08, P = 0.023), and less increase in temporal horn volume (beta −0.25 ± 0.09, P = 0.005). The associations persisted in fully adjusted models.
Conclusion: parental longevity is associated with better brain ageing in middle-aged offspring.
 

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