This is so blasted obvious, you need to look at the damage to the brain, that will correlate to impairments.
http://www.frontiersin.org/Journal/10.3389/fneur.2013.00178/full?utm_source=newsletter&utm_medium=email&utm_campaign=Neurology-w46-2013
Joyce L. Chen1,2,3 and
Gottfried Schlaug1*
- 1Neuroimaging and Stroke Recovery
Laboratories, Department of Neurology, Beth Israel Deaconess Medical
Center, Harvard Medical School, Boston, MA, USA
- 2Heart and Stroke Foundation Canadian Partnership in Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada
- 3Department of Physical Therapy, University of Toronto, Toronto, ON, Canada
Functional and structural reorganization in the brain occurs after
stroke. The ability to predict motor outcomes may depend on patterns of
brain functional and structural connectivity. We tested the hypothesis
that alterations in motor transcallosal and corticospinal connections
correlate with motor impairment in patients with chronic stroke. Eleven
ischemic stroke patients underwent the Upper Extremity Fugl-Meyer
(UE-FM) assessment, resting state functional magnetic resonance imaging,
and diffusion tensor imaging (DTI). Twelve healthy control subjects
underwent DTI. We assessed the temporal coupling in neural activity
between interhemispheric motor cortex, and white matter integrity by
means of fractional anisotropy (FA), in the transcallosal motor fibers
and corticospinal tract. Partial correlation analyses were performed to
determine whether these connectivity measures correlate with Upper UE-FM
scores. Patients compared to controls had reduced FA in common voxels
of transcallosal motor and ipsilesional corticospinal fibers. Within the
patient group those with higher interhemispheric motor cortex
connectivity and higher FA in the transcallosal motor fibers were less
impaired. The results show that markers of functional and structural
motor cortex connectivity correlate with motor impairment in the chronic
stage of stroke.
More at link.
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