And if we know the answer to this we can get a lot closer to 100% recovery.
http://www.frontiersin.org/Journal/10.3389/fncom.2013.00150/full?utm_source=newsletter&utm_medium=email&utm_campaign=Neuroscience-w48-2013
James B. Aimone1 and
Jason P. Weick2*
- 1Cognitive Modeling Group, Sandia National Laboratories, Albuquerque, NM, USA
- 2Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA
Mathematical modeling of anatomically-constrained neural networks has
provided significant insights regarding the response of networks to
neurological disorders or injury. A logical extension of these models is
to incorporate treatment regimens to investigate network responses to
intervention. The addition of nascent neurons from stem cell precursors
into damaged or diseased tissue has been used as a successful
therapeutic tool in recent decades. Interestingly, models have been
developed to examine the incorporation of new neurons into intact adult
structures, particularly the dentate granule neurons of the hippocampus.
These studies suggest that the unique properties of maturing neurons,
can impact circuit behavior in unanticipated ways. In this perspective,
we review the current status of models used to examine damaged CNS
structures
with particular focus on cortical damage due to stroke.
Secondly, we suggest that computational modeling of cell replacement
therapies can be made feasible by implementing approaches taken by
current models of adult neurogenesis. The development of these models is
critical for generating hypotheses regarding transplant therapies and
improving outcomes by tailoring transplants to desired effects.
Much more at link for your doctor to tell you about.
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