Is this another player in the neuronal cascade of death? To join the other four. Is your doctor going to come up with a research project to prove this hypothesis? If not, then who the hell will?
2. excitotoxicity
3. Capillaries that don't open due to pericytes
4. Inflammatory action leaking through the blood brain barrier.
The latest here:
Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: a “Lysosomocentric” Hypothesis for Ischemic Brain Damage
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
* Final gross prices may vary according to local VAT.
Abstract
This is a speculative
review of the role of the lysosome in ischemic cell death in the
mammalian brain. In particular, it focuses on the role of the
permeabilization of the lysosomal membrane to proteins (LMP) as a major
mechanism of cell death in mild, but lethal, ischemic insults. The first
section of the review outlines the evidence that this is the case,
using the relatively few extant studies of mammalian brain. In the
second section of the review, the mechanism by which an ischemic insult
might lead to LMP is discussed. A metabolic sequence including NMDA
receptor activation, activation of phospholipase A2 and production of
free radicals, and also the activation of calpain are shown to be
critical. The remainder of the section speculates on the actual agent(s)
which may be causing the lysosomal membrane change, based on extensive
literature references. There is currently no knowledge of the actual
mechanism. The third section considers potential targets of the released
lysosomal proteases and other proteins that might mediate the lethal
effects of LMP, focusing largely on the mitochondria as the target.
Again, this is speculative as the targets are not known. Finally, the
fourth section addresses the level of importance that LMP has in the
process of ischemic cell death and concludes that it may well play the
major role during mild but lethal ischemic insults. This novel,
so-called “lysosomocentric,” hypothesis is briefly critiqued. The
therapeutic potential of this conclusion is then discussed.
Dean, I think stroke survivors who read your blog aren't primarily interested in preventing damage to other people's brains; they're interested in recovering their abilities. For me, preventing the neuronal cascade of death is right there with the topic of stroke prevention - nothing to do with me. Selfish I am, I know, but I want legit research into recovery techniques; I want a recovery protocol, not platitudes like "Every blah, blah..." and "Never give up."
ReplyDeleteI agree but what I am trying to do is get survivors to ask their doctor why there is nothing that would have prevented much of the damage in the first place. What you are asking for is effective stroke protocols which also don't exist. So much to do and no one doing anything.
Delete