http://stroke.ahajournals.org/content/early/2013/11/14/STROKEAHA.113.002246.abstract
- Barbara J. Jefferis, PhD,
- Peter H. Whincup, PhD,
- Olia Papacosta, MSc and
- S. Goya Wannamethee, PhD
+ Author Affiliations
- Correspondence to Barbara J. Jefferis, PhD, Department of Primary Care and Population Health, UCL, Rowland Hill St, London NW3 2PF, United Kingdom. E-mail b.jefferis@ucl.ac.uk
Abstract
Background and Purpose—Older adults have the highest risks of stroke and the lowest physical activity levels. It is important to quantify how walking
(the predominant form of physical activity in older age) is associated with stroke.
Methods—A total of
4252 men from a UK population-based cohort reported usual physical
activity (regular walking, cycling, recreational
activity, and sport) in 1998 to 2000. Nurses
took fasting blood samples and made anthropometric measurements.
Results—Among 3435
ambulatory men free from cardiovascular disease and heart failure in
1998 to 2000, 195 first strokes occurred during
11-year follow-up. Men walked a median of 7
(interquartile range, 3–12) hours/wk; walking more hours was associated
with lower
heart rate, D-dimer, and higher forced
expiratory volume in 1 second. Compared with men walking 0 to 3
hours/wk, men walking
4 to 7, 8 to 14, 15 to 21, and >22 hours
had age- and region-adjusted hazard ratios (95% confidence intervals)
for stroke
of 0.89 (0.60–1.31), 0.63 (0.40–1.00), 0.68
(0.35–1.32), and 0.36 (0.14–0.91), respectively, P
(trend)=0.006. Hazard ratios were somewhat attenuated by adjustment for
established and novel risk markers (inflammatory
and hemostatic markers and cardiac function
[N-terminal pro-brain natriuretic peptide]) and walking pace, but linear
trends
remained. There was little evidence for a
dose–response relationship between walking pace and stroke; comparing
average pace
or faster to a baseline of slow pace, the
hazard ratio for stroke was 0.65 (95% confidence interval, 0.44–0.97),
which was
fully mediated by time spent walking.
Conclusions—Time spent walking was associated with reduced risk of onset of stroke in dose–response fashion, independent of walking pace.
Walking could form an important part of stroke-prevention strategies in older people.
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