Gait impairment is a major determinant of disability after stroke. At least 1 of 2 stroke survivors suffers from persistent hemiparetic gait deficits resulting in reduced mobility.1,2
http://nnr.sagepub.com/content/26/1/85.full
- Christoph Globas, MD1,2,3
- Clemens Becker, MD2
- Joachim Cerny1
- Judith M. Lam1,3
- Ulrich Lindemann, PhD2
- Larry W. Forrester, PhD4
- Richard F. Macko, MD4
- Andreas R. Luft, MD1
- 1University Hospital of Zürich, Zürich, Switzerland
- 2Robert Bosch Krankenhaus, Stuttgart, Germany
- 3University of Tübingen, Tübingen, Germany
- 4University of Maryland, Baltimore, MD, USA
- Christoph Globas, MD, Clinic of Neurology, University Hospital of Zürich, Frauenklinikstr 26, CH-Zürich, Switzerland Email: christoph.globas@usz.ch
Abstract
Background and objective. Ambulatory subjects after stroke may benefit from gait-oriented cardiovascular fitness training, but trials to date have
not primarily assessed older persons. Methods.
Thirty-eight subjects (age >60 years) with residual hemiparetic gait
were enrolled >6 months after stroke. Participants
were randomized to receive 3 months (3×/week)
progressive graded, high-intensity aerobic treadmill exercise (TAEX) or
conventional
care physiotherapy. Primary outcome measures were
peak exercise capacity (Vo2peak) and sustained walking
capacity in 6-minute walks (6MW). Secondary measures were gait velocity
in 10-m walks, Berg Balance
Scale, functional leg strength (5 chair-rise),
self-rated mobility (Rivermead Mobility Index), and quality of life
(SF-12).
Results. Thirty-six participants completed the study (18 TAEX, 18 controls). TAEX but not conventional care improved Vo2peak (difference 6.4 mL/kg/min, P < .001) and 6MW (53 m, P < .001). Likewise, maximum walking speed (0.13 m/s, P = .01), balance (P < .05), and the mental subscore of the SF-12 (P < .01) improved more after TAEX. Gains in Vo2peak correlated with the degree at which training intensity could be progressed in the individual participant (P < .01). Better walking was related to progression in treadmill velocity and training duration (P < .001). Vo2peak and 6MW performances were still higher 1 year after the end of training when compared with the baseline, although endurance
walking (6MW) at 1 year was lower than immediately after training (P < .01). Conclusion. This trial demonstrates that TAEX effectively improves cardiovascular fitness and gait in persons with chronic stroke.
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