Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Friday, February 14, 2014

Ambulance magnesium treatment fails to improve stroke outcome

Did they consider the fact that maybe they didn't analyze the data enough and maybe didn't have enough hemorrhage patients? Looking at the 3 month timeframe is wrong, they should have been looking at scans on a daily basis to see that the neuronal cascade of death was slowed down.
There are six causes of the neuronal cascade of death, this may have only fixed one of them, did they even know which one they were trying to fix?  This other trial was promising:
Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial
Does absolutely no one in the stroke medical world have any clue to what has been tested/researched in the past? That alone proves that the existing stroke associations need to be destroyed and start over.
Preferably with me at the head.  I'm in great ranting form today. Argh.gifBashHead.gifRant-On.gif Soapbox.gif giljotiini.gif 
Giving intravenous magnesium to stroke patients soon after the start of symptoms, in an attempt to protect brain cells deprived of oxygen, failed to improve stroke-related disability 3 months later, according to research presented at the American Stroke Association’s International Stroke Conference 2014.
Investigators showed that paramedics can successfully deliver intravenous medications to most stroke patients within an hour after symptoms begin. This is the “golden hour” the time in which patients have the best chance to survive and avoid long-term neurological damage.
“We hoped magnesium would be beneficial, but in any case the study was a success in demonstrating we can get a drug to patients in this early time frame when there is the greatest amount of threatened brain tissue that might still be saved. There are lots of other promising agents in the pipeline that could be helpful and we now have a system for testing and using them,” said Jeffrey L. Saver, M.D., principal investigator and professor of neurology and director of the stroke center at UCLA.
Currently, the only immediate treatment for clot-caused strokes is the clot-dissolving medication tissue plasminogen activator (tPA). However, this drug can’t be given until the patient arrives at the hospital and a clot is confirmed by CT scan or other imaging.
“Giving tPA in the ambulance before brain imaging is not an option – it could harm patients having a bleeding type of stroke. Neuroprotective drugs can be delivered in the field as they are safe for both types of stroke,” Saver said.
The Field Administration of Stroke Therapy – Magnesium Phase 3 Clinical Trial (FAST-MAG) tested whether IV magnesium, a potential neuroprotective agent, could be delivered in a timely manner and was effective in improving the neurological outcome of patients. Magnesium was chosen because, in animal studies, it dilates blood vessels in the brain, increasing blood flow, and counters the dangerous calcium overload that occurs in cells that are deprived of oxygen. In smaller human trials, magnesium given up to 12 hours after a stroke showed neither harm nor benefit overall, but there were indications that it was helpful in the small number of patients who received it within a few hours of stroke onset.
In the current study, IV magnesium proved to be safe, resulting in no more serious adverse reactions than placebo infusions. However, there was no benefit in outcome. Ninety days after the stroke, the average level of disability in both magnesium and placebo patients was 2.7 on the modified Rankin scale, indicating between a slight and moderate level of disability in which patients are unable to carry out their previous activities without assistance.
FAST-MAG involved collaboration between 315 ambulances, 40 emergency medical service agencies, 60 receiving hospitals, and 2,988 paramedics in Los Angeles and Orange Counties in California. Between 2005 and 2012, paramedics evaluated and began infusions of study medications to 1,700 patients (42.7 percent female, average age 69) within 2 hours of symptom onset.
In the study, the median time for receiving treatment was 45 minutes after symptoms began, and 74 percent of patients were started on treatment within an hour.
“The FAST-MAG investigators are enormously indebted to the paramedics who implemented the trial and showed incredible skill and dedication as first responders for this devastating brain condition,” Saver said.

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