5-30% of patients come to the ER with a wake-up stroke. Because they don't know when it occurred they can't get tPA. I can't tell if this editorial has an answer but my answer is simple. Use a smaller bolus and deliver it directly to the clot with magnetic nanoparticles. With direct and smaller delivery the chance of bleeding should be reduced substantially. But since I have no medical training its obvious that this is a stupid idea.
http://cjns.metapress.com/content/l0140k320x74l427/?id=L0140K320X74L427
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,294 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
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