What does your doctor think of the results or is the pressure from drug compnies too high?
http://www.bmj.com/content/347/bmj.f7267
- Adam D M Briggs, academic clinical fellow,
- Anja Mizdrak, researcher,
- Peter Scarborough, senior researcher
- Correspondence to: A D M Briggs adam.briggs@dph.ox.ac.uk
- Accepted 27 November 2013
Abstract
Objective
To model the effect on UK vascular mortality of all adults over 50
years old being prescribed either a statin or an apple a day.
Design Comparative proverb assessment modelling study.
Setting United Kingdom.
Population Adults aged over 50 years.
Intervention
Either a statin a day for people not already taking a statin or an
apple a day for everyone, assuming 70% compliance and no change in
calorie consumption. The modelling used routinely available UK
population datasets; parameters describing the relations between
statins, apples, and health were derived from meta-analyses.
Main outcome measure Mortality due to vascular disease.
Results
The estimated annual reduction in deaths from vascular disease of a
statin a day, assuming 70% compliance and a reduction in vascular
mortality of 12% (95% confidence interval 9% to 16%) per 1.0 mmol/L
reduction in low density lipoprotein cholesterol, is 9400 (7000 to
12 500). The equivalent reduction from an apple a day, modelled using
the PRIME model (assuming an apple weighs 100 g and that overall calorie
consumption remains constant) is 8500 (95% credible interval 6200 to
10 800).
Conclusions Both nutritional
and pharmaceutical approaches to the prevention of vascular disease may
have the potential to reduce UK mortality significantly. With similar
reductions in mortality, a 150 year old health promotion message is able
to match modern medicine and is likely to have fewer side effects.
No comments:
Post a Comment