This report makes it much more likely to be able to get enough resveratrol naturally. Only 400 bottles of red wine daily instead of 1000 bottles a day. You do know that the natural form is much better than taking it as a supplement? I'm sure your doctor would agree.
Then there is the resveratrol preconditioning which reduces the impact of a stroke. Your doctor should know the exact amount of bottles of red wine to be consumed daily both as a prevention of ischemic harm and a reduction in Alzheimers. If your doctor doesn't know this, call up the damned hospital president and ask why s/he has such incompetent people in place. Someone has to light a fire under our stroke medical professionals. With 10 million yearly stroke survivors all screaming for results from their doctors we may finally get to the tipping point where stroke is talked about with breathless anticipation for research solutions. Not just the lazy press releases.
Resveratrol Moderates Alzheimer’s Severity
Arandomized, placebo-controlled, double-blind, multicenter study has discovered that high doses of resveratrol may be beneficial for fighting Alzheimer’s disease (AD).1 Resveratrol is a member of the stilbene family, which acts as an antifungal molecule in a variety of plant species in response to pathogen attack or under stress conditions such as UV radiation and exposure to heavy metal ions. Over the years, resveratrol has been touted as a possible antidote to Alzheimer’s disease, cancer, diabetes and many other conditions.In the new report, the first study of resveratrol in people with AD, researchers reported that a purified form of resveratrol—what “purified” means wasn’t clarified*—helped stabilize amyloid-beta40 (Aβ40) levels in the blood and cerebrospinal fluid of those who consumed resveratrol, compared to the placebo group, which saw their Aβ40 levels declined. Deposition of Aβ in the brain is a pathological hallmark of AD. There are two major isoforms of Aβ: Aβ42 and Aβ40. A decrease in Aβ40 is seen in the blood and cerebrospinal fluid as dementia worsens and Alzheimer’s disease progresses. Stabilization is good.
From Blood to Brain
This decline is thought to be a sign that Aβ40 was being taken from their blood and deposited in Alzheimer’s patients’ brains. Those taking resveratrol, however, showed little or no change in Aβ40 levels in their blood.
The study included 119 patients randomly assigned to either high doses of resveratrol (n = 64) or placebo (n = 55). Ranging from age 50 to 90, the mean age for the resveratrol group was 70; the mean age for the placebo group was 73.
A decrease in Aβ40 is seen in
the blood and cerebrospinal fluid as
dementia worsens and Alzheimer’s
disease progresses. Resveratrol
stabilizes blood and cerebral levels.
the blood and cerebrospinal fluid as
dementia worsens and Alzheimer’s
disease progresses. Resveratrol
stabilizes blood and cerebral levels.
Although accumulation of Aβ40 in the brain is a marker for AD, these same individuals have lower levels of Aβ40 outside of the brain. Thus, the study’s finding suggests that resveratrol could help change the balance from Aβ40 buildup in the brain to circulating protein in the body, where it is less reflective of neurodegeneration.
At the highest dose given in the study (2,000 mg resveratrol per day), you’d have to drink at least 400 bottles of red wine per day to obtain that much resveratrol—but in the study, that amount was represented by four 500 mg capsules per day. Parenthetically, by using a non-natural form of resveratrol, the researchers were granting superior status to extracts or synthetic forms.
The finding suggests that resveratrol
could change the balance from Aβ40
buildup in the brain to circulating
protein in the body, where it is less
reflective of neurodegeneration.
could change the balance from Aβ40
buildup in the brain to circulating
protein in the body, where it is less
reflective of neurodegeneration.
However, this is not the first time that resveratrol has been connected to AD. In fact, the earliest research goes back to 1998, and includes 200 scientific papers involving AD and resveratrol.
During this time there have been many hypotheses, many of which have been tested again and again.
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