Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, April 15, 2016

Immune cells help the brain to self-heal after a stroke

Your doctor should be jumping for joy with this news and updating your stroke protocols, but that won't occur because I bet your doctor doesn't even know about these results. Whatever that secretion is should be studied as part of a clinical research study. A great stroke association would be putting out a RFP(Request for Proposal) to researchers to answer the question of how to  replicate the benefits. Foundations should be able to fund such innovative and interesting research. Never mind, this will not occur with the current lack of stroke leadership and strategy.
http://medicalxpress.com/news/2016-04-immune-cells-brain-self-heal.html
After a stroke, there is inflammation in the damaged part of the brain. Until now, the inflammation has been seen as a negative consequence that needs to be abolished as soon as possible. But, as it turns out, there are also some positive sides to the inflammation, and it can actually help the brain to self-repair.
"This is in total contrast to our previous beliefs", says Professor Zaal Kokaia from Lund University in Sweden.
Zaal Kokaia, together with Professor of Neurology Olle Lindvall, runs a research group at the Lund Stem Cell Center that, in collaboration with colleagues at the Weizmann Institute in Israel, is responsible for these findings. Hopefully, these new data will lead to new ways of treating stroke in the future. The study was recently published in the international Journal of Neuroscience.
When stroke occurs, the in the damaged area of the die, causing an inflammation that attracts cells from the immune system. Among them you find – a type of produced in the .
The monocytes travel to the inflamed area, and here they develop into macrophages that clear out any dead tissue. But this is not all that they do: they also secrete substances that help the brain repair the damage.
"This is what we, together with Michal Schwartz's research group in Israel, have been able to show", says Zaal Kokaia.
Most recover at least partly over time. This spontaneous improvement is well known, but not its exact cause. The Lund researchers now believe that the improvement is partly due to the substances released by the immune cells.
In their study, they actually performed the opposite: in animal model of stroke they were able to ablate monocytes from the blood. Mice with decreased number of circulating monocytes were much less successful in their recovery from stroke than mice whose immune system was functioning as normal.
Today's treatment against stroke primarily involves dissolving or removing the blood clot that caused the stroke. However, such treatments must be performed in the very early phase after the insult, which means that most stroke patients are too late to receive it. A future treatment method – one that could be based on the Lund researchers' new findings and that aims to promote self-healing – could be implemented later. This treatment could start at some point within the first few weeks, rather than within the first few hours after a stroke.
The Lund researchers have focused on what happens in the brain during this later stage. Among other things, they were the first to show that, after a , the brain produces new nerve cells from its own stem cells. They now want to proceed with animal experiments to see if the self-healing can be improved by adding more monocytes to the brain, or by stimulating the production of monocytes in bone marrow.
"Obviously, there is a difference between mice and humans, but there is no indication that our brains function differently in this regard", says Olle Lindvall. Except that mice may not be trusted to translate to humans;

Modeling Immunity and Inflammation in Stroke Can Mice Be Trusted?

He further argues that this new insight concerning the positive effects of inflammation could also be applied to other diseases. The Lund research group's collaborators from Israel have obtained similar results in cases of spinal cord injury.
"This is no less than a paradigm shift within research, as has in many instances been seen as a purely negative phenomenon that should be combatted using any means available. We now realise that this view is much too simplistic", says Olle Lindvall.
More information: S. Wattananit et al. Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice, Journal of Neuroscience (2016). DOI: 10.1523/JNEUROSCI.4317-15.2016

Journal reference: Journal of Neuroscience search and more info website
Provided by: Lund University search and more info website

No comments:

Post a Comment