http://wso.sagepub.com/content/early/2016/04/12/1747493016643851.abstract?
- Julie Bernhardt1,2⇑
- Karen Borschmann1,2
- Lara Boyd3
- S Thomas Carmichael4
- Dale Corbett5,6
- Steven C Cramer7
- Tammy Hoffmann8
- Gert Kwakkel9
- Sean I Savitz10
- Gustavo Saposnik11,12
- Marion Walker13
- Nick Ward14,15
- 1NHMRC Centre for Research Excellence in Stroke Rehabilitation and Recovery, Victoria, Australia
- 2The Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia
- 3Department of Physical Therapy and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, BC, Canada
- 4Departments of Neurology and Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, USA
- 5Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada
- 6Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, University of Ottawa, Ottawa, Canada
- 7Departments of Neurology, Anatomy & Neurobiology, and Physical Medicine & Rehabilitation, University of California, Irvine, USA
- 8Centre for Research in Evidence-Based Practice, Bond University, Gold Coast, Queensland, Australia
- 9Department of Rehabilitation Medicine, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
- 10Stroke Program, McGovern Medical School, UTHealth, Houston, Texas, USA
- 11Department of Medicine, University of Toronto, Toronto, Canada
- 12Stroke Outcomes Research Center, Li Ka Shing Knowledge Institute, Toronto, Canada
- 13Division of Rehabilitation and Ageing, University of Nottingham, Nottingham, UK
- 14Sobell Department of Motor Neuroscience UCL Institute of Neurology, Queen Square, London, UK
- 15National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
- Julie Bernhardt, The Florey Institute of Neuroscience and Mental Health, 245 Burgundy Street Heidelberg, Victoria 3084 Australia. Email: julie.bernhardt@florey.edu.au
Abstract
Stroke recovery is the next frontier in
stroke medicine. While growth in rehabilitation and recovery research is
exponential,
a number of barriers hamper our ability to rapidly
progress the field. Standardized terminology is absent in both animal
and
human research, methods are poorly described,
recovery biomarkers are not well defined, and we lack consistent
timeframes
or measures to examine outcomes. Agreed methods and
conventions for developing, monitoring, evaluating and reporting
interventions
directed at improving recovery are lacking, and
current approaches are often not underpinned by biology. We urgently
need
to better understand the biology of recovery and
its time course in both animals and humans to translate evidence from
basic
science into clinical trials. A new international
partnership of stroke recovery and rehabilitation experts has committed
to advancing the research agenda. In May 2016, the
first Stroke Recovery and Rehabilitation Roundtable will be held, with
the aim of achieving an agreed approach to the
development, conduct and reporting of research. A range of methods will
be
used to achieve consensus in four priority areas:
pre-clinical recovery research; biomarkers of recovery; intervention
development,
monitoring and reporting; and measurement in
clinical trials. We hope to foster a global network of researchers
committed
to advancing this exciting field. Recovery from
stroke is challenging for many survivors. They deserve effective
treatments
underpinned by our evolving understanding of brain
recovery and human behaviour. Working together, we can develop
game-changing
interventions to improve recovery and quality of
life in those living with stroke.
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