Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, August 17, 2017

New Material to Help Repair Brain Tissue Damaged by Stroke

And with a great stroke association following up on promising research this would be looked at to create stroke protocols for stroke repair. We need to repair 12 km (7.5 miles) of connections for each minute of infarct. But fucking nothing will be done with this because we have NO stroke leadership and NO stroke strategy. You're screwed because all the stroke medical professionals in the world can't get their act together and solve all the problems in stroke
https://www.medgadget.com/2017/08/new-material-help-repair-brain-tissue-damaged-stroke.html
One of the reasons why strokes are so devastating is that brain tissue does not exhibit the same healing mechanisms as other tissues that repair themselves quickly. Integrin proteins are responsible for some of the healing processes, including getting new cells to move and having them adhere to the extracellular matrix, and these are not strongly present within damaged brain tissue. In order to get the brain to heal itself better than on its own, a team led by UCLA scientists has come up with a material that is similar to the extracellular matrix and that promotes the activity of integrin to heal nearby tissues.
The hydrogel-based material, which has already been successfully tried in post-stroke mice, features vascular endothelial growth factor and a molecule that promotes α3/α5β1 integrin binding, which the researchers have shown leads to much stronger and less leaky blood vessels than a molecule that promotes αvβ3 integrin binding.
The studied mice demonstrated considerable repair of their brain tissues following a stroke, which bodes well that humans will also react similarly to this new approach to stroke care. Hopefully clinical trials will soon be underway to validate the new technology.
Study in Nature Materials: Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability…
Via: UCLA…

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