Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, March 15, 2019

Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomised controlled trials

A useless conclusion since protocols weren't identified on how to use those drugs.  I would fire the mentors and senior researchers that allowed such a lazy objective to be researched.

Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomised controlled trials


Firth N1, Barker RN, Hayward KS, Bernhardt J, Bellingan M, Gunnarsson R.

Abstract

OBJECTIVE:

To investigate the efficacy and safety of drug interventions to promote motor recovery post-stroke.(We need protocols, NOT THIS CRAPOLA.)

DATA SOURCES:

CENTRAL, CINAHL, Embase, MEDLINE, SCOPUS and Web of Science.

STUDY SELECTION:

Published human randomized controlled trials in which the primary intervention was a drug administered to promote motor recovery post-stroke, vs placebo.

DATA EXTRACTION:

Standardized pro forma used to extract safety and efficacy data; Cochrane Collaboration risk of bias assessment tool performed to assess risk of bias.

DATA SYNTHESIS:

Fifty randomized controlled trials from 4,779 citations were included. An overall trend of high risk of attrition (n = 27) and reporting bias (n = 36) was observed. Twenty-eight different drug interventions were investigated, 18 of which demonstrated statistically significant results favouring increased motor recovery compared with control intervention. Forty-four studies measured safety; no major safety concerns were reported.

CONCLUSION:

Candidate drug interventions promoting motor recovery post-stroke were identified, specifically selective serotonin reuptake inhibitors and levodopa; however, the high risk of bias in many trials is concerning. Drugs to improve motor function remain an important area of enquiry. Future research must focus on establishing the correct drug intervention to be administered at an optimal dose and time, combined with the most effective adjuvant physical therapy to drive stroke recovery.

KEYWORDS:

rehabilitation; stroke; pharmaceutical preparations
PMID:
30805655
DOI:
10.2340/16501977-2536
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