Deans' stroke musings: Lifetime estrogen exposure linked to stroke after menopause

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, February 2, 2023

Lifetime estrogen exposure linked to stroke after menopause

FYI, ask your doctor what this means.

Lifetime estrogen exposure linked to stroke after menopause

Women in China may be at greater risk for stroke events following menopause, according to a study published in Neurology.

“Lifetime cumulative estrogen exposure due to reproductive factors could potentially be a useful indicator of patients’ risk of stroke events following menopause,” Leying Hou, PhD, of Zhejiang University School of Medicine in China, and colleagues wrote. “However, further research is needed on the underlying biological, behavioral and social mechanisms linking estrogen exposure with stroke risk across female patients’ lifespans.”

Woman with menopause — Lifetime cumulative exposure to estrogen was found to be associated with stroke events after menopause. *Source: Adobe Stock*

Researchers conducted a population-based, longitudinal, prospective cohort study using data from the China Kadoorie Biobank study to evaluate the link between lifetime cumulative estrogen exposure and stroke. They included 122,939 postmenopausal women, aged 40 to 79 years, without prior history of stroke from 2004 to 2008.

Hou and colleagues assessed cumulative estrogen exposure using reproductive lifespan (RLS), endogenous estrogen exposure (EEE) and total estrogen exposure (TEE).

During a median follow-up of 8.9 years, researchers identified 15,139 new-onset stroke cases, subcategorized as 12,853 ischemic stroke (IS), 2,580 intracerebral hemorrhage (ICH) and 269 subarachnoid hemorrhage (SAH), using health insurance data and a disease registry system.

According to results, compared with the lowest quartile of RLS, the highest quartile had a lower risk for total stroke (adjusted HR = 0.95; 95% CI, 0.92-0.98), IS (aHR = 0.95; 95% CI, 0.92-0.98) and ICH (aHR = 0.87; 95% CI, 0.81-0.94).

Further, when comparing the highest quartile with the lowest, EEE and TEE showed a graded association with descending risk for total stroke (EEE: aHR = 0.85; 95% CI, 0.82-0.89; TEE: aHR = 0.87; 95% CI, 0.84-0.9), IS (aHR = EEE: 0.86; 95% CI, 0.83-0.9; TEE: aHR = 0.86; 95% CI, 0.83-0.89) and ICH (EEE: aHR = 0.73; 95% CI, 0.65-0.81; TEE: aHR = 0.83; 95% CI, 0.76-0.91).

“Lifetime cumulative estrogen exposure due to reproductive factors, as indicated by RLS, EEE and TEE, is associated with stroke events among postmenopausal patients,” Hou and colleagues wrote. “For RLS, those in the highest quartile were found to have a lower risk of total stroke, IS and ICH. As for EEE and TEE, higher quartiles were found to have a graded association with a descending risk of total stroke, IS and ICH.”