Deans' stroke musings: Impact of collateral circulation on early outcome and risk of hemorrhagic complications after systemic thrombolysis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, November 4, 2012

Impact of collateral circulation on early outcome and risk of hemorrhagic complications after systemic thrombolysis

Maybe the stroke world is finally getting the idea that blood flow to the penumbra is essential immediately after the stroke. Otherwise the neuronal cascade of death will kills lots of neurons. But they don't mention pericytes.
http://onlinelibrary.wiley.com/doi/10.1111/j.1747-4949.2012.00922.x/abstract;jsessionid=64AF10A8E750D042FE3C30B89DE55D6E.d02t02

Background

In stroke patients, collateral flow can rapidly be assessed on computed tomography angiography (CTA).

Aims

In this study, the impact of baseline collaterals on early outcome and risk of symptomatic intracerebral hemorrhages after systemic thrombolysis in patients with proximal arterial occlusions within the anterior circulation were analyzed.

Methods

Collateralization scores were determined on the CT angiography source images (0 = absent; 1 ≤ 50%, 2 greater than 50% but less than 100%, and 3 = 100% collateral filling) of patients with distal intracranial carotid artery and/or M1 segment occlusions treated from 2008 to December 2011. A collateral score of 0 to 1 was designated as poor and 2 to 3 as good collateral vessel status. Outcome variables included in hospital mortality, favorable outcome at discharge (modified Rankin score ≤ 2), and rates of symptomatic intracerebral hemorrhage based on the European–Australasian Acute Stroke Study II definition.

Results

Among 246 subjects (mean age of 74 years; median National Institutes of Health Stroke Scale N at admission 14), 205 patients (83%) had good collaterals, whereas 41 patients (17%) had poor collaterals, respectively. Patients with poor collaterals had significantly higher rates of in-hospital mortality (41% vs. 12%, P less than 0·001), of symptomatic intracerebral hemorrhage (15% vs. 4·9%, P less than 0·05) and had significantly lower rates of favorable early clinical outcome (0% vs. 28%, P less than 0·001) compared with those with good collaterals. The grade of collateralization was independently associated with in-hospital mortality (P less than 0·001), early clinical outcome (P less than 0·01), and rates of symptomatic intracerebral hemorrhage (P less than 0·01).

Conclusion

Patients with proximal arterial occlusions within the anterior circulation and poor baseline collaterals have a poor early functional outcome and high rates of symptomatic intracerebral hemorrhage after systemic thrombolysis. Since similar findings have also been reported after endovascular therapy, strategies to improve collateral blood flow should be assessed in this patient population.