Our researchers should be able to use this to plan exactly how to grow neurons and blood vessels to support those neurons.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=127474&CultureCode=en
Stem cells can be grown on biocompatible scaffolds to form complex
tissues such as bone, cartilage, and muscle for repair and regeneration
of damaged or diseased tissue. However, to function properly, the cells
must often grow in a specific pattern or alignment. An innovative method
for creating a stretched polymer scaffold that can support complex
tissue architectures is described in an article in Tissue Engineering, Part C, Methods, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com). The article is available on the Tissue Engineering, Part C, Methods website (http://www.liebertpub.com/ten).
Zu-yong
Wang and a team of researchers from National University of Singapore,
Nanyang Technological University, KK Women's and Children's Hospital,
and Duke-NUS Graduate Medical School, in Singapore, developed a
reproducible method that involves stretching a polymer thin film to
produce scaffolds that can support the growth of human mesenchymal stem
cells. The stretching process creates orientated 3-dimensional
micro-grooves on the surface of the films, and these formations promote
consistent alignment and elongation of stem cells as they grow and
develop into tissues on and around the resorbable scaffold.
The
authors present their work in the article, "Biomimetic 3D anisotropic
geometries by uniaxial stretch of poly(?-caprolactone) films for
mesenchymal stem cell proliferation, alignment and myogenic
differentiation."
(http://online.liebertpub.com/doi/full/10.1089/ten.tec.2012.0472)
“The researchers developed a very elegant method to promote cell behavior," says John Jansen, DDS, PhD, Methods Co-Editor-in-Chief
and Professor and Chairman, Department of Biomaterials, Radboud
University Nijmegen Medical Center, The Netherlands.
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