Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, August 26, 2013

Incidental Findings on Brain MR Imaging in Older Community-Dwelling Subjects Are Common but Serious Medical Consequences Are Rare: A Cohort Study

But do you really think you can trust their interpretations of the MRI data?
What about the MRI scanning of the dead salmon?
Subject. One mature Atlantic Salmon (Salmo salar) participated in the fMRI study.
The salmon was approximately 18 inches long, weighed 3.8 lbs, and was not alive at
the time of scanning.
Task. The task administered to the salmon involved completing an open-ended
mentalizing task. The salmon was shown a series of photographs depicting human
individuals in social situations with a specified emotional valence. The salmon was
asked to determine what emotion the individual in the photo must have been
experiencing.
Can we conclude from this data that the salmon is engaging in the
perspective-taking task? Certainly not. What we can determine is that random
noise in the EPI timeseries may yield spurious results if multiple comparisons
are not controlled for. Adaptive methods for controlling the FDR and FWER
are excellent options and are widely available in all major fMRI analysis
packages. We argue that relying on standard statistical thresholds (p < 0.001)
and low minimum cluster sizes (k > 8) is an ineffective control for multiple
comparisons. We further argue that the vast majority of fMRI studies should
be utilizing multiple comparisons correction as standard practice in the
computation of their statistics.
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http://www.ncbi.nlm.nih.gov/pubmed/23967214

Source

Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom.

Abstract

OBJECTIVES:

Incidental findings in neuroimaging occur in 3% of volunteers. Most data come from young subjects. Data on their occurrence in older subjects and their medical, lifestyle and financial consequences are lacking. We determined the prevalence and medical consequences of incidental findings found in community-dwelling older subjects on brain magnetic resonance imaging.

DESIGN:

Prospective cohort observational study.

SETTING:

Single centre study with input from secondary care.

PARTICIPANTS:

Lothian Birth Cohort 1936, a study of cognitive ageing.

MAIN OUTCOME MEASURES:

Incidental findings identified by two consultant neuroradiologists on structural brain magnetic resonance imaging at age 73 years; resulting medical referrals and interventions.

PRIMARY AND SECONDARY OUTCOME MEASURES:

PREVALENCE OF INCIDENTAL FINDINGS BY INDIVIDUAL CATEGORIES: neoplasms, cysts, vascular lesions, developmental, ear, nose or throat anomalies, by intra- and extracranial location; visual rating of white matter hyperintensities and brain atrophy.

RESULTS:

There were 281 incidental findings in 223 (32%) of 700 subjects, including 14 intra- or extracranial neoplasms (2%), 15 intracranial vascular anomalies (2%), and 137 infarcts or haemorrhages (20%). Additionally, 153 had moderate/severe deep white matter hyperintensities (22%) and 176 had cerebral atrophy at, or above, the upper limit of normal (25%) compared with a normative population template. The incidental findings were unrelated to white matter hyperintensities or atrophy; about a third of subjects had both incidental findings and moderate or severe WMH and a quarter had incidental findings and atrophy. The incidental findings resulted in one urgent and nine non-urgent referrals for further medical assessment, but ultimately in no new treatments.

CONCLUSIONS:

In community-dwelling older subjects, incidental findings, including white matter hyperintensities and atrophy, were common. However, many findings were not of medical importance and, in this age group, most did not result in further assessment and none in change of treatment.

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