I'm not sure I'd want a pesticide injected into my brain even if nitric oxide and CoQ10 increased. But ask your doctor what they think about it. Most of us received rat poison(warfarin) so its not out of the question.
http://link.springer.com/article/10.1007/s00580-013-1807-4
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Abstract
We investigated the
effect of a single injection of rotenone into the striatum on the
development of oxidative stress, nigrostriatal cell injury and motor
alterations in rats. Rotenone (1, 3, 5 and 9 mM; 5 μL/rat) or the
vehicle (dimethyl sulfoxide) was injected into the right striatum.
Control rats received the vehicle only. Rats were allowed to recover
from the operation and were tested for behavioural changes on 7th and
30th days after rotenone injection. Biochemical markers of oxidative
stress including malondialdehyde (MDA), reduced glutathione (GSH),
nitric oxide, paraoxonase 1 (PON1) activity and Q10 enzyme as well as
monoamine neurotransmitters in the brain were determined after 30 days
of rotenone treatment. Histopathology and tyrosine hydroxylase
immunohistochemistry were also performed.
Results:
Intrastriatal injection of rotenone at 9 mM caused immediate death of
rats. No mortality was observed with the lower concentrations of the
pesticide. Rotenone at 1–5 mM resulted in increased brain oxidative
stress in a dose-dependent manner. MDA increased by 23.5–64.9 %, while
GSH decreased by 20.4–24.1 % in the contralateral cerebral hemisphere.
Nitric oxide increased by 20.2–41.7 % in ipsilateral cortex. PON1
activity decreased by 12.5–38.2 % in ipsilateral cerebral cortex and by
31.2–65.3 % in ipsilateral striatum, respectively, but coenzyme Q10
increased in the ipsilateral cortex by 21–26.3 %. There was decreased
dopamine and serotonin in the ipsilateral striatum after rotenone
injection. Tyrosine hydroxylase immunoreactivity was markedly decreased
in ipsilateral substantia nigra in the rotenone-treated in contrast to
the vehicle-treated rats. Rotenone increased the number of degenerated
cells in substantia nigra in a dose-dependent manner. It also caused
depletion of pigment granules from cells. Degenerative changes were also
observed in the contralateral hippocampus and cortex especially after
the highest dose of rotenone. The number of spontaneous rears made
during 30 min in the cylinder was decreased in both limbs; the decrease
being more evident in the ipsilateral side. Thus, a single intrastriatal
injection of rotenone (a) caused a significant nigrostriatal
degeneration and loss of dopamine and serotonin from the striatum; (b)
elicited cell degeneration in the hippocampus and cortex; (c) induced
oxidative stress and neuronal injury (this latter effect of rotenone was
not region specific); and (d) the motor deficits (decreased rearing
activity) occurred in both limbs
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