My first post on this was 2.5 years ago, and if anybody had been listening to me we would have had drugs already being delivered to the brain via this method. Everybody in the stroke medical world is vastly more stupid than me. And I have an iron-clad excuse(stroke) for being stupid. Slightly arrogant there Dean.
Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics
Abstract
Exosomes have emerged
as prominent mediators of neurodegenerative diseases where they have
been shown to carry disease particles such as beta amyloid and prions
from their cells of origin to other cells. Their simple structure and
ability to cross the blood–brain barrier allow great opportunity to
design a “makeup” with drugs and genetic elements, such as siRNA or
miRNA, and use them as delivery vehicles for neurotherapeutics. Their
role in neuroprotection is evident by the fact that they are involved in
the regeneration of peripheral nerves and repair of neuronal injuries.
This review is focused on the role of exosomes in mediating
neurodegeneration and neuroprotection.
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