http://informahealthcare.com/doi/abs/10.3109/00016489.2010.516013
January 2011, Vol. 131, No. 1
,
Pages 96-100
(doi:10.3109/00016489.2010.516013)
Yoshimasa Imoto 1, Akihiro Kojima 2, Youko Osawa 2, Hiroshi Sunaga 3 & Shigeharu Fujieda 1
1Division
of Otorhinolaryngology Head & Neck Surgery, Department of Sensory
and Locomotor Medicine, Faculty of Medical Science, University of Fukui,
Fukui
2Department of Otorhinolaryngology, Tannan Regional Medical Center, Fukui
3Department of Otorhinolaryngology, Maizuru Kyosai Hospital, Kyoto, Japan
Abstract
Conclusions:
We conclude that the capsaicin inhalation test is useful to directly
assess cough reflex and sensation around the larynx, while it indirectly
reflects central nervous system function. Objectives: To understand the state of the cough reflex before patients with dysphagia start eating. Methods:
We studied the cough reflex by the capsaicin inhalation test in 21
patients with dysphagia and 12 healthy persons without dysphagia. Results:
The control group showed a cough reflex at a capsaicin concentration of
2.61 μM (0.98–7.80), while patients with mild dysphagia did so at 7.28
μM (1.95–15.6), those with moderate dysphagia at 22.07 μM (15.6–62.5),
and those with severe dysphagia at 71.75 μM (31.2–250). Control vs mild p < 0.01, control vs moderate p < 0.01, control vs severe p < 0.01, mild vs moderate p < 0.01, mild vs severe p < 0.01, moderate vs severe p
< 0.05. There was a significant correlation between the grade of
dysphagia and the threshold capsaicin concentration that provoked a
cough reflex (ρ = –0.796, p < 0.001).
Read More: http://informahealthcare.com/doi/abs/10.3109/00016489.2010.516013
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